Mole Mapping

Mole mapping is a procedure used for surveillance of skin for malignant melanoma. Skin is examined, and through the use of dermoscopy, lesions of concern are identified and evaluated. Typically, mole mapping is done by means of photography or digital images of the whole body surface. This is kept as a record for future comparison to identify new lesions, or […]

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Generating Megakaryocytes and Platelets from Adipocytes

Adipocytes can be converted into mesenchymal stem cells, which can then be converted into megakaryocytes. These megakaryocytes can be used to produce platelets, which may be a source of safer platelet transfusions. What are adipocytes? Adipocytes are specialized cells that store energy as fat, they are mainly comprised of adipose tissues. Adipocytes differentiate from mesenchymal stem cells; thus, they are […]

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Post-Infectious Irritable Bowel Syndrome

Post-infectious irritable bowel syndrome is triggered by a gastroenteritis infection. This results in the expression of various symptoms including abdominal pain and diarrhea. What is irritable bowel syndrome? Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disease, which is characterized by symptoms such as abdominal pain or discomfort, bloating, and irregularities with stool, such as diarrhea or constipation. However, […]

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Insulin Resistance and Parkinson's Disease

A growing pool of evidence suggests that Type 2 diabetes mellitus (T2DM) and Parkinson’s disease (PD) may share common pathological mechanisms, and that the presence of T2DM increases the risk of developing PD by 40%. Measuring blood sugar level. Image Credit: Neirfy / Shutterstock How is T2DM Connected to PD? PD, the second most common neurodegenerative disorder after Alzheimer’s disease, […]

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Treating Breast Cancer Using Antibiotics

Skip to: A Toxin Capable of Halting a Signaling Pathway Achieving Tumour Growth Inhibition The Promise of Drug Repurposing in the Future Triple-negative breast cancer (TNBC) describes the form of the disease that lacks the expression of 3 receptors: estrogen, progesterone, and HER2. Up to 15% of breast cancers are considered to be TNBC, which is correlated with an elevated […]

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Morris receives stem cell foundation investigator award

Samantha A. Morris, PhD, an assistant professor of developmental biology and of genetics at Washington University School of Medicine in St. Louis, has received the New York Stem Cell Foundation’s Robertson Stem Cell Investigator Award. She is one of three investigators receiving the award this year. It recognizes outstanding early-career scientists and provides each $1.5 million over five years to […]

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Breaking the dogma: Key cell death regulator has more than one way to get the job done

Scientists at St. Jude Children’s Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted cells showing that more than one mechanism can trigger the process. The findings appeared online today in the Journal of Experimental Medicine. “Our findings break the existing dogma that RIPK1 kinase activity is required for […]

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New way of measuring white blood cell function offers better insights to help patients with sepsis

Caring for a patient with sepsis requires walking a treatment tightrope. Clinicians must identify the pathogen that is causing a patient’s infection, carefully monitor the patient’s response to antibiotics and supportive measures and race against the clock to prevent potential organ failure and death. Most of the time, physicians can control the infection itself. What ultimately leads to multi-organ system […]

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