What is Gain-of-Function Research?

Gain-of-function research refers to the serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host tropism by applying selective pressure to a culture. Image Credit: vchal/Shutterstock.com This is performed in a research context to understand the way in which a pathogen adapts to environmental pressures, allowing disease control measures to be better planned, and potential vaccines and therapies […]

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tezepelumab

tezepelumab Amgen Announces Tezepelumab Biologics License Application Submitted To U.S. FDA THOUSAND OAKS, Calif., May 10, 2021 /PRNewswire/ — Amgen (NASDAQ:AMGN) today announced its partner AstraZeneca (NASDAQ:AZN) submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for tezepelumab, a potential first-in-class medicine in severe asthma. The submission is supported by positive clinical trial results from the PATHFINDER clinical program including the pivotal NAVIGATOR Phase […]

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Pregnancy and Vaccines

Some vaccinations are recommended to women trying to get pregnant and those who are already pregnant. The antibodies introduced into the mother’s immune system via these vaccines can cross the placenta and also give their babies a level of immunity from serious illnesses. However, while certain vaccinations are beneficial and recommended for pregnant women, others are not suitable and are […]

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Consortium to investigate role of neurofilament light chain in neurodegenerative diseases

Clinical scientists at Washington University School of Medicine in St. Louis and University College London are collaborating with pharmaceutical companies AbbVie, Biogen, Bristol Myers Squibb and Roche to investigate the role of neurofilament light (NfL) chain in neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson’s disease, Huntington’s disease and Alzheimer’s disease. NfL is a protein that provides structural support to […]

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What is Neuropsychiatric Lupus (NPSLE)?

Neuropsychiatric lupus (NPSLE), which is often referred to as central nervous system (CNS) lupus, can cause lupus patients to be afflicted with a variety of neuropsychiatric issues ranging from headaches and depression to seizures and a number of demyelinating conditions. Image Credit: vitstudio / Shutterstock.com Overview of lupus Systemic lupus erythematosus (SLE), which is formally referred to as lupus, is […]

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COVID-19 and Mental Health Research

The COVID-19 pandemic has exerted a significant impact on every aspect of humanity. Its profound effect on the respiratory and circulatory systems has been documented in severe levels of morbidity and mortality worldwide. Whilst the extent to which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus may adversely affect brain functioning remains under investigation, the impact on psychiatric morbidity […]

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Lung Cancer Causes

The main cause of lung cancer is smoking, although non-smokers can also develop the condition. Smoking and other risk factors for lung cancer are described below. Smoking is the cause of lung cancer in more than 90% of cases and is the single biggest risk factor for lung cancer. There are more than 60 different toxins in tobacco smoke that can […]

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Breastfeeding and Hormones

There are several hormones that regulate the making and ejection of milk from human breasts as well as from the breasts of all female mammals after childbirth. The initiation of breastfeeding in all mammals including humans is an effort from both the mother and the baby. For example while human mothers hold their baby close to their breast while attempting […]

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