What is Binswanger Disease?

Binswanger disease, also known as Binswanger encephalopathy and subcortical dementia is a progressive neurological condition. It is a kind of vascular leukoencephalopathy that can cause cognitive impairment and neurological abnormalities. Diagnosing the disease can be challenging. Arteriosclerosis and thromboembolism can cause the disease by impairing the blood arteries that supply the brain's white matter and deep structures (basal ganglia and […]

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For children, young adults with recurrent AML, immunotherapy shows promise

An immunotherapy harnessing the immune system’s “natural killer” cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return. Now, researchers at Washington University School of Medicine in St. Louis have shown, in a small clinical trial, that the same natural killer cells also can help some children and young adults with recurrent AML and […]

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What is Schizoaffective Disorder?

Schizoaffective disorder is a combination of schizophrenia and a major mood disorder – such as depression or bipolar disorder. Individuals with schizoaffective disorder experience a combination of alterations in emotions and thinking. There is a lot of debate amongst psychologists as to whether schizoaffective disorder should be a separate disorder from schizophrenia. Some researchers argue that schizoaffective disorder should be […]

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What is "long haul" COVID and How Does it Relate to the Extended Symptoms of Other Viruses?

As of July 8, 2021, almost 186 million people have been infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with over 4 million people dying because of this virus. Approximately 80% of individuals who acquire the coronavirus disease 2019 (COVID-19), which is the disease caused by SARS-CoV-2, will experience mild to moderate symptoms, whereas about 5% will […]

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What is Gain-of-Function Research?

Gain-of-function research refers to the serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host tropism by applying selective pressure to a culture. Image Credit: vchal/Shutterstock.com This is performed in a research context to understand the way in which a pathogen adapts to environmental pressures, allowing disease control measures to be better planned, and potential vaccines and therapies […]

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tezepelumab

tezepelumab Amgen Announces Tezepelumab Biologics License Application Submitted To U.S. FDA THOUSAND OAKS, Calif., May 10, 2021 /PRNewswire/ — Amgen (NASDAQ:AMGN) today announced its partner AstraZeneca (NASDAQ:AZN) submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for tezepelumab, a potential first-in-class medicine in severe asthma. The submission is supported by positive clinical trial results from the PATHFINDER clinical program including the pivotal NAVIGATOR Phase […]

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Pregnancy and Vaccines

Some vaccinations are recommended to women trying to get pregnant and those who are already pregnant. The antibodies introduced into the mother’s immune system via these vaccines can cross the placenta and also give their babies a level of immunity from serious illnesses. However, while certain vaccinations are beneficial and recommended for pregnant women, others are not suitable and are […]

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Consortium to investigate role of neurofilament light chain in neurodegenerative diseases

Clinical scientists at Washington University School of Medicine in St. Louis and University College London are collaborating with pharmaceutical companies AbbVie, Biogen, Bristol Myers Squibb and Roche to investigate the role of neurofilament light (NfL) chain in neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson’s disease, Huntington’s disease and Alzheimer’s disease. NfL is a protein that provides structural support to […]

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