T cell biomarker predicts which CLL patients will respond to CAR T cell therapy

Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia (CLL) don’t respond to chimeric antigen receptor (CAR) T cell therapy, and the answer is tied to how primed patients’ immune systems are before the therapy is administered. While 80 percent of patients with advanced acute lymphoblastic leukemia (ALL) treated with the CAR T […]

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Massive single-cell survey of kidney cell types reveals new paths to disease

The kidney is a highly complex organ – far beyond a simple filter. Its function requires intricate interactions between many highly specialized cell types to extract waste, balances body fluids, form urine, regulate blood pressure, and secrete hormones. New research from a team in the Perelman School of Medicine at the University of Pennsylvania shines a light on specific cell […]

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Scientists develop novel cancer cell culture test kit for personalised, precise cancer therapy

A team of scientists led by Professor Lim Chwee Teck, Principal Investigator at the Mechanobiology Institute, Singapore (MBI) and the Department of Biomedical Engineering at the National University of Singapore (NUS) and NUS Ph.D. graduate Dr. Khoo Bee Luan, has developed a novel and robust cancer cell-based assay that could help clinicians to diagnose cancer, monitor the disease state and […]

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