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New tools to boost the delivery of drugs to cancer tumours

02.05.2018 Health Problems

The treatment of cancer tumours is made complex by their microenvironment and the abnormalities of the blood vessels sustaining them. The EU-funded NeoNaNo project has developed methods to improve drug delivery to tumours and improve the efficacy of anticancer therapy. Drug delivery to tumours is difficult. The blood vessels they depend on are abnormally structured, heterogeneously distributed and relatively poorly […]

New lab study reveals how breast cancer drug can accelerate cancer cell growth

01.05.2018 Health Problems

The breast cancer drug lapatinib which is designed to shrink tumours can sometimes cause them to grow in the lab, according to a new study published in eLife. By understanding the molecular basis of this phenomenon, scientists hope that their findings will lead to safer treatment decision-making and drug design in the future. Lapatinib is used in combination with other […]

New tools could uncover important answers for Alzheimer’s researchers

30.04.2018 Health Problems

Alzheimer’s disease currently affects more than 5.5 million Americans and is one of the costliest diseases to treat, according to the Alzheimer’s Association. Characterized by a buildup of plaque in the brain, few animal models exist that researchers could use to study this devastating disorder. Now, a team of researchers from the University of Missouri, publishing in PLOS ONE, developed […]

Brain cells record their activity in gene expression, new study finds

27.04.2018 Health Problems

From burning your palm on a hot pan handle to memorizing the name of a new acquaintance, “anytime you experience something, your neurons are active,” says Kelsey Tyssowski, a graduate student in genetics at Harvard Medical School. Different experiences stimulate different patterns of activity in brain cells. Researchers want to track these activity patterns to better understand how the brain […]

Mouse study identifies new target for human accelerated aging syndrome

27.04.2018 Health Problems

Scientists from the University of Cambridge have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS), which is characterised by premature ageing. In a paper published today in Nature Communications, scientists provide preclinical data showing that chemical inhibition or genetic deregulation of the enzyme N-acetyltransferase 10 (NAT10) leads to significant health and lifespan gains in […]

Largest-ever study of thyroid cancer genetics finds new mutations, suggests immunotherapy

27.04.2018 Health Problems

University of Colorado Cancer Center researchers recently completed the largest-ever study of thyroid cancer genetics, mining the data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers. In addition to identification of specific genes that may drive these cancers and thus provide attractive targets for treatment, the researchers found that in several samples of advanced […]

Study shows a new approach to treating patients with stage IV Wilms tumor

26.04.2018 Health Problems

A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology. The outcomes of the study, “Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children’s Oncology Group AREN0533 Study”, will be a game-changer in treating Wilms tumor […]

Increased smartphone use and selfie-taking linked to lower connection to nature and higher anxiety in new study

25.04.2018 Health Problems

A team of academics at the University of Derby has conducted the first study into the link between smartphone use, the number of selfies a person takes and how connected they feel to nature – and what this means for their health and wellbeing. With Britain now a ‘smartphone society’ (68 percent of adults currently own a smartphone), concerns about […]

Prospects for new malaria interventions

25.04.2018 Health Problems

April 25 marks World Malaria Day, an international event commemorated every year in recognition of global efforts to control malaria, one of the world’s oldest and deadliest diseases. This year’s theme, “Ready to beat Malaria”, underscores the collective goal and commitment of the global malaria community. In a recent review published in Open Biology, David Baker, Professor of Malaria Parasite […]

Radiotherapy offers new treatment option for liver cancer

24.04.2018 Health Problems

A novel technique that delivers high doses of radiation to tumors while sparing the surrounding normal tissue shows promise as a curative treatment option for patients with early-stage liver cancer, according to a study published online in the journal Radiology. Curative treatment options for early-stage hepatocellular carcinoma (HCC), the most common type of liver cancer, include surgery, liver transplantation and […]

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