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A phase I, first-in-human study led by The University of Texas MD Anderson Cancer Center reveals for the first time, an investigational drug that is effective and safe for patients with cancers caused by an alteration in the receptor tyrosine kinase known as RET. The drug appears to be promising as a potential therapy for RET-driven cancers, such as medullary […]
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A new study to find a safer, efficacious and more patient-friendly treatment and improved diagnostic tools for people living with visceral leishmaniasis (VL) has begun in eastern Africa, within the new Afri-KA-DIA Consortium with funding from The European & Developing Countries Clinical Trials Partnership (EDCTP). The large-scale Phase III clinical trial seeks to assess the efficacy and safety of a […]
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A Northwestern Medicine study published in Developmental Cell provides new insights into how cytomegalovirus—a common virus in the herpes family—replicates within human cells, and identifies proteins that may be therapeutically targeted to suppress infection. Human cytomegalovirus (HCMV) is widespread around the world, infecting between 60 to 100 percent of all adults. There is currently no cure or vaccine for HCMV; […]
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Researchers have discovered a new class of drug that has the potential to help cancer patients who no longer respond to existing therapies. The drug may not become available to patients for a number of years yet, but researchers believe that if clinical trials are successful, it could be used to tackle a variety of treatment-resistant cancers. Patients with breast […]
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Government and other scientists are proposing a new way to define Alzheimer’s disease—basing it on biological signs, such as brain changes, rather than memory loss and other symptoms of dementia that are used today. The move is aimed at improving research, by using more objective criteria like brain scans to pick patients for studies and enroll them sooner in the […]
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The research community now has a new framework toward developing a biologically-based definition of Alzheimer’s disease. This proposed “biological construct” is based on measurable changes in the brain and is expected to facilitate better understanding of the disease process and the sequence of events that lead to cognitive impairment and dementia. With this construct, researchers can study Alzheimer’s, from its […]
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Research led by a psychologist at the University of California, Riverside, shows that bilinguals regulate, or suppress, their native language when reading in a second language. Many in media and in science often assume that reading or speaking in a second language—one that has been learned later in life than the native or first language—is always going to be difficult. […]
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Researchers from the School of Medicine in Ribeirão Preto (FMRP), at the University of São Paulo (USP), in collaboration with international groups, have developed indices that provide information about the prognosis of cancers, aid in the choice of the most appropriate therapy and identify potential targets for the development of new drugs. Their paper, titled “Machine Learning Identity Stemness Features […]
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A Pakistani official says authorities have launched a new polio vaccination drive, aiming to reach 38.7 million children under the age of 5. Pakistan is one of few countries where polio is still endemic, along with Afghanistan and Nigeria. Dr. Rana Mohammad Safdar, the national coordinator for polio eradication, says that some 260,000 polio workers will take part in the […]
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Prescriptions are not enough—diet changes and nutrition education make the difference in people with diabetes, according to a study published in the Journal of the Academy of Nutrition and Dietetics. Researchers from the Physicians Committee for Responsible Medicine set up a study in a private endocrinology office in Washington, D.C. After working hours, the researchers put the waiting room chairs […]
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