New recommendations for endoscopic eradication therapy in Barrett’s esophagus

The latest issue of GIE: Gastrointestinal Endoscopy, the official journal of the American Society for Gastrointestinal Endoscopy (ASGE), includes a new society guideline on use of endoscopic eradication therapy Barrett’s esophagus. A new guideline by the ASGE Standards of Practice Committee offers evidence-based recommendations and clinical guidelines addressing key issues related to Endoscopic Eradication Therapy (EET) in the management of […]

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Massive single-cell survey of kidney cell types reveals new paths to disease

The kidney is a highly complex organ – far beyond a simple filter. Its function requires intricate interactions between many highly specialized cell types to extract waste, balances body fluids, form urine, regulate blood pressure, and secrete hormones. New research from a team in the Perelman School of Medicine at the University of Pennsylvania shines a light on specific cell […]

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New rapid-fire method using pathology images, tumor data may help guide cancer therapies

By combining data on pathology images of 13 types of cancer and correlating that with clinical and genomic data, a Stony Brook University-led team of researchers are able to identify tumor-infiltrating lymphocytes (TILs), called TIL maps, which will enable cancer specialists to generate tumor-immune information from routinely gathered pathology slides. Published in Cell Reports , the paper details how TIL […]

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Mathematical modeling offers new way to understand variable responses to targeted therapy

Cancer therapies that target a specific protein have improved outcomes for patients. However, many patients eventually develop resistance to these targeted therapies and their cancer comes back. It is believed that differences among tumor cells, or heterogeneity, may contribute to this drug resistance. Moffitt Cancer Center researchers are using a unique approach by combining typical cell culture studies with mathematical […]

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New technique makes heart valve replacement safer for some high-risk patients

Scientists have developed a novel technique that prevents coronary artery obstruction during transcatheter aortic valve replacement (TAVR), a rare but often fatal complication. The method, called Bioprosthetic Aortic Scallop Intentional Laceration to prevent Iatrogenic Coronary Artery obstruction (BASILICA), will increase treatment options for high-risk patients who need heart valve procedures. The findings by researchers at the National Institutes of Health […]

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Sulfur amino acid restriction could amount to new dietary approach to health

The longevity and health improvements seen in animals on sulfur amino acid-restricted diets could translate to people, according to Penn State College of Medicine researchers who recently conducted a review of published studies. More research is needed to confirm the benefits in people, the scientists said. Amino acids are the building blocks of all proteins in the body. A subcategory […]

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