Heart-on-a-chip mimics drug response seen in humans

Researchers from TARA Biosystems, Inc. and GlaxoSmithKline (GSK) today published data demonstrating that TARA’s engineered heart-on-a-chip system replicated drug responses found in adult humans. The findings, published in the journal Toxicological Sciences, show TARA’s 3-D-cardiac tissue platform can predict how human hearts will respond to a wide range of drugs, something that has been a challenge in pre-clinical models until […]

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Changes in radial pulse during menopause may reflect CV risk

(HealthDay)—Changes in the harmonics of the radial pulse wave during menopause may reflect cardiovascular risk, according to a study presented at the American Heart Association Basic Cardiovascular Sciences 2019 Scientific Sessions, held from July 29 to Aug. 1 in Boston. Chih-Yu Chen, M.D., from Taipei City Hospital in Taiwan, and colleagues assessed the effect of age, menopause, and body mass […]

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CRISPR used to reduce symptoms of muscular dystrophy in mice models

A team of researchers from Canada, the U.S. and Sweden has found that editing a gene involved in producing proteins that promote muscle strength in muscular dystrophy mice models could reduce symptoms. In their paper published in the journal Nature, the group describes their experiments with mice and what they learned from them. Muscular dystrophy is an inherited condition in […]

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Researchers unveil experimental compound to block therapeutic target in blood cancer

Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer. They also developed an experimental therapeutic to block the signal and slow tumor growth. The researchers reported in the journal Proceedings of the National Academy of Sciences they identified a novel therapeutic target for primary effusion […]

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Early EEG helps predict cardiac arrest outcomes in comatose

(HealthDay)—Early electroencephalography (EEG) reliably predicts the outcome of comatose patients after cardiac arrest, according to a study recently published in the Annals of Neurology. Barry J. Ruijter, M.D., Ph.D., from the University of Twente in Enschede, Netherlands, and colleagues assessed whether early EEG can reliably predict outcomes among comatose patients after cardiac arrest. Blinded reviewers assessed five-minute EEG epochs at […]

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