To assess a cell’s health, follow the glucose

A new spectroscopic technique reveals that glucose use in live cells provides valuable information about the functional status of cells, tissues, and organs. Shifts in a cell’s use of glucose can signal changes in health and progress of disease. How a cell uses glucose has long been a window on overall health. However, existing glucose-imaging tools have only been able […]

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Researchers unveil experimental compound to block therapeutic target in blood cancer

Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer. They also developed an experimental therapeutic to block the signal and slow tumor growth. The researchers reported in the journal Proceedings of the National Academy of Sciences they identified a novel therapeutic target for primary effusion […]

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Humans aren’t designed to be happy

A huge happiness and positive thinking industry, estimated to be worth US$11 billion a year, has helped to create the fantasy that happiness is a realistic goal. Chasing the happiness dream is a very American concept, exported to the rest of the world through popular culture. Indeed, “the pursuit of happiness” is one of the US’s “unalienable rights.” Unfortunately, this […]

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Recarbrio OK’d for complicated urinary tract, intra-abdominal infections

(HealthDay)—The antibacterial drug product Recarbrio (imipenem, cilastatin, and relebactam) has been approved to treat complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) in adults, the U.S. Food and Drug Administration announced. Recarbrio, a three-drug combination injection, is intended to be used for patients who have limited or no alternative antibacterial drugs to treat their infection, Ed Cox, M.D., […]

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Early EEG helps predict cardiac arrest outcomes in comatose

(HealthDay)—Early electroencephalography (EEG) reliably predicts the outcome of comatose patients after cardiac arrest, according to a study recently published in the Annals of Neurology. Barry J. Ruijter, M.D., Ph.D., from the University of Twente in Enschede, Netherlands, and colleagues assessed whether early EEG can reliably predict outcomes among comatose patients after cardiac arrest. Blinded reviewers assessed five-minute EEG epochs at […]

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Researchers tie metabolic enzyme to obesity and fatty liver disease

Researchers from Clemson University’s Environmental Toxicology Program have published research connecting an enzyme associated with detoxification to obesity and fatty liver disease, especially in males. William Baldwin, professor and graduate program coordinator in the College of Science’s department of biological sciences, and members of his laboratory used a novel mouse model developed in their laboratory to study the role of […]

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How DNA outside cells can be targeted to prevent the spread of cancer

Cell-free DNA (cfDNA) is DNA found in trace amounts in blood, which has escaped degradation by enzymes. Scientists from Tokyo University of Science, led by Prof Ryushin Mizuta, have now discovered exactly how cfDNA is generated. They also talk about the applications of DNase1L3—the enzyme mainly responsible for generating cfDNA—as a novel molecule to prevent the spread of tumors. Prof […]

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Scientists map high-risk areas for hepatitis E

EPFL scientists have created the first world map of regions with the highest prevalence of the hepatitis E virus (HEV). They hope that their map—freely available online—will help governments and NGOs design more effective prevention campaigns based on reliable data, particularly when it comes to setting up refugee camps. The scientists’ research has just been published in Scientific Reports. In […]

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