Early life environment may lead to high blood pressure in children

Where a mother lives and the temperature outside while she is pregnant, among other environmental factors, can impact whether her child is prehypertensive or hypertensive during childhood, according to a study published today in the Journal of the American College of Cardiology. Exposure to negative lifestyle factors in pregnancy, such as obesity, physical inactivity, poor diet, and alcohol and tobacco […]

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Concussions linked to erectile dysfunction in former NFL players

Former professional football players who have experienced concussion symptoms, including loss of consciousness, disorientation or nausea after a head injury, are more likely to report low testosterone and erectile dysfunction (ED), according to research published Aug. 26 in JAMA Neurology. The research—based on a survey of more than 3,400 former NFL players representing the largest study cohort of former professional […]

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Using math to help treat Alzheimer’s, Parkinson’s and other diseases

Protein aggregation—in which misfolded proteins clump together to form large fibrils—has been implicated in many diseases including Alzheimer’s, Parkinson’s, and type II diabetes. While the exact role these fibrils play in diseases isn’t fully understood, many of the current treatments for diseases like Alzheimer’s and Parkinson’s target the aggregation process. However, finding the right treatment protocols for these drugs, which […]

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MDM2 counteracts resistance to CDK4/6 inhibitors for melanoma therapy

A study from Vanderbilt-Ingram Cancer Center and the Department of Veterans Affairs led by Anna Vilgelm, MD, Ph.D., and Ann Richmond, Ph.D., has identified a possible second-line treatment for melanoma patients. The potential treatment would render CDK4/6 inhibitors, a class of drugs prescribed for some breast cancers, also effective against melanoma by combining the inhibitors with MDM2 compounds, which are […]

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