Next-generation ALS drug silences inherited form of the disease in animal models

NIH-funded researchers delayed signs of amyotrophic lateral sclerosis (ALS) in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1 (SOD1). The results, published in the Journal of Clinical Investigation, suggest the newer version of the drug may be effective at treating an inherited form of the disease caused by mutations in SOD1. Currently, […]

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Link found between resilience to dyslexia and gray matter in the frontal brain

Dyslexia, a reading disorder, is characterized by a difficulty in “decoding”—navigating between the visual form and sounds of a written language. But a subset of dyslexic people, dubbed “resilient dyslexics,” exhibit remarkably high levels of reading comprehension despite difficulties decoding. What is the precise mechanism that allows certain individuals with dyslexia to overcome their low decoding abilities and ultimately extract […]

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Are neurological disorders the result of brain evolution mistakes?

A team of researchers affiliated with several institutions in Australia has proposed that some neurological disorders might have their roots in evolutionary mistakes. In their paper published in the journal Nature Neuroscience, the group describes their ideas and possible paths of research moving forward. As scientists delve ever deeper into our brains as part of an effort to understand how […]

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The ‘secret sauce’ for high-performing NICUs

Leaders of neonatal intensive care units (NICUs) across the nation share the same play books as they strive to provide safe, high-quality medical and surgical care for vulnerable newborns. A growing number of quality collaborations share best practices and evidence-based guidelines across the nation in the hopes of replicating quality and safety success stories while minimizing harms. Still, NICUs that […]

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Study provides insight into how dying neurons control eating behaviors of the brain microglia

A new Mount Sinai study, published July 23 in the journal Nature Neuroscience, provides important insight into how microglia, cells that form a branch of the immune system inside the brain, go about their job of clearing out dying and non-functional neurons—and how they sometimes mistakenly attack healthy neurons, an event that can play a role in neurodegenerative diseases like […]

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The cause of prostate cancer progression to the incurable stage has likely been uncovered

Researchers at the University of Oulu in Finland have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism (SNP) rs11672691 influences prostate cancer aggressiveness. Their findings also suggest ways to improve risk stratification and clinical treatment for advanced prostate cancer. The study is published in the journal Cell. Three billion base pairs […]

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