novel Archives - Family Medicine News

Novel genetic signature that can predict some kinds of breast cancer is identified

18.12.2019 Health Problems

Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases. The research, published in the journal PLOS Genetics, combined a study of the genes involved in retinopathy, […]

Scientists reveal novel oncogenic driver gene in human gastrointestinal stromal tumors

24.10.2019 Health Problems

Sarcomas—cancers that arise from transformed mesenchymal cells (a type of connective tissue)—are quite deadly. Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase. Micro-GISTs are a smaller variation of clinical GISTs and are found in one-third of the general population without clinical symptoms. Although the micro-GISTs and […]

Novel study documents marked slowdown of cell division rates in old age

22.10.2019 Health Problems

In a novel study comparing healthy cells from people in their 20s with cells from people in their 80s, researchers at the Johns Hopkins Kimmel Cancer Center say they have documented that cell division rates appear to consistently and markedly slow down in humans at older ages. The researchers say the findings may help explain why cancer—long considered a disease […]

Novel regulator of mitochondrial cell death reveals a promising target for cancer therapy

20.09.2019 Health Problems

Researchers at The Wistar Institute have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target. They also found that expression of MFF is regulated by Myc, a ubiquitous mediator of cell proliferation that contributes to development of many cancer types. These results were published online in […]

Novel approach leads to potential sepsis prevention in burn patients

04.09.2019 Health Problems

Immediately following severe burns, bacteria reach the wound from different sources, including the patient’s skin, gastrointestinal tract, respiratory tracts and health care-related human contact. Within the wound, bacteria multiply, establish an infection and move from the infected burn wound into the bloodstream, causing serious complications like sepsis, multiple-organ failure and death. In modern burn units, more than 50% of deaths […]

Scientists uncover novel strategy to target common type of cancer

26.03.2019 Health Problems

Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife. The findings, originally posted on bioRxiv, suggest that targeting a protein called Werner syndrome helicase (WRN) could represent a novel opportunity for treating a subgroup of cancer patients with microsatellite instability-high (MSI-H) tumors. MSI is a […]

Novel imaging technology may reduce biopsies for breast tumors

16.01.2019 Health Problems

In American women, breast cancer is the most common cancer and the second-leading cause of cancer death. While routine screening helps to detect breast cancer, existing technology frequently identifies suspicious lesions that turn out not to be cancer. In fact, up to 80 percent of the biopsies performed reveal the suspicious areas are not cancerous. A team of scientists at […]

In vitro cell culture findings could lead to novel interventions for schizophrenia

01.12.2018 Health Problems

A study recently published in Translational Psychiatry, a Nature journal, has shown how using cultured cells from patients with psychotic disorders, such as schizophrenia, to investigate abnormalities in nerve connections in the brain could lead to new treatments. Strong correlations were observed between the findings in the cells in culture—grown outside the body in a controlled environment—and findings from brain […]

Study points to novel epigenetic target for Alzheimer’s Disease

06.11.2018 Health Problems

A research team at the University of Miami Miller School of Medicine’s Center for Therapeutic Innovation (CTI) has identified a novel epigenetic drug target to simultaneously normalize multiple deficits in Alzheimer’s disease (AD), the most common form of dementia in the elderly and the sixth leading cause of death in the U.S., according to the Alzheimer’s Association. The study, titled […]

Novel gene mutation found in lymphatic disorder

28.08.2018 Health Problems

Pediatric researchers have identified a gene mutation that causes a serious lymphatic condition, and used that knowledge to restore normal lymphatic vessels in model animals. The laboratory findings may lead to a new therapy for patients with this type of abnormal lymphatic circulation. “This discovery offers a potential avenue for intervening with existing drugs to treat patients with this complex, […]

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