Genetically engineered 3-D human muscle transplant in a murine model

A growing need for tissues and organs in surgical reconstruction is addressed by the promising field of tissue engineering. For instance, muscle atrophy results from severe traumatic events including deep burns and cancer, requiring site/donor compatible surgical reconstruction. The existing ‘gold standard’ treatment in reconstructive surgery incorporates autologous flaps, although the technique is limited by low anatomical availability and donor […]

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Mouse study mirrors human findings that link chemotherapy and APOE4 to cognitive issues

The research, led by Georgetown University Medical Center (GUMC) investigators and published in Neurotoxicity Research, complements findings from another GUMC-led study, published Oct. 3, that found a subset of breast cancer patients who experience long lasting cognitive deficits also have the APOE4 gene. Cancer survivors often report memory difficulties and this study, published in the Journal of Clinical Oncology (JCO), […]

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Human hair cells from a test tube

Researchers from the University of Bern and Bern University Hospital have managed for the first time to differentiate human inner ear cells in a laboratory from somatic progenitors and to investigate their origin. This will make it possible to develop new treatment methods for hearing impairment in the future. About 5% of the world population suffers from hearing impairment. Disabling […]

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Automated detection of focal epileptic seizures in a sentinel area of the human brain

Patients with focal epilepsy that does not respond to medications badly need alternative treatments. In a first-in-humans pilot study, researchers at the University of Alabama at Birmingham have identified a sentinel area of the brain that may give an early warning before clinical seizure manifestations appear. They have also validated an algorithm that can automatically detect that early warning. These […]

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Human microbiome influences rotavirus vaccine response

In a proof-of-concept study in healthy adult men, scientists in the Netherlands found that microbiome manipulation with antibiotics influenced the response to oral rotavirus vaccine. Specifically, they found higher levels of viral shedding in those receiving antibiotic treatment prior to vaccination compared with controls receiving no antibiotic treatment prior to vaccination. The study is a human demonstration that altering the […]

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Researchers report novel method to quickly make therapeutic proteins from human blood

UMBC researchers report novel method to quickly make therapeutic proteins from human blood Personalized medicine has incredible potential, but current approaches are still too expensive and time-consuming to have a big impact. A new paper in Scientific Reports looks at how to extract cellular protein synthesis machinery from human blood, and, by adding recombinant DNA to the extract, to produce […]

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