Cancer drug and antidepressants provide clues for treating brain-eating amoeba infections

The amoeba Naegleria fowleri is commonly found in warm swimming pools, lakes and rivers. On rare occasions, the amoeba can infect a healthy person and cause severe primary amebic meningoencephalitis, a “brain-eating” disease that is almost always fatal. Other than trial-and-error with general antifungal medications, there are no treatments for the infection. Researchers at Skaggs School of Pharmacy and Pharmaceutical […]

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Study details incidence and timing of immunotherapy-related fatalities

Vanderbilt-Ingram Cancer Center researchers have answered questions about the incidence and timing of rare but sometimes fatal reactions to the most widely prescribed class of immunotherapies. Their research, which appeared Sept. 13 in JAMA Oncology, is the largest evaluation of fatal immune checkpoint inhibitor toxicities published to date. They determined that although these severe events can happen, the risks are […]

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Study links BAP1 protein to tumor suppression in kidney, eye, bile duct and mesothelioma cancers

Researchers at The University of Texas MD Anderson Cancer Center have shown how BRCA-associated protein 1 (BAP1) serves as a tumor suppressor gene in kidney, eye, bile duct, mesothelioma and other cancers by regulating a form of cell death called ferroptosis, opening up a potential new area of therapy research. Findings from the study, led by Boyi Gan, Ph.D., associate […]

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Break the pain cycle—relax, sleep and recover

Extreme pain is highly destructive, often accompanied by fatigue, sleep disturbance, decreased appetite and mood changes. A novel nerve activity modulator technology addresses the pain and welcome sleep follows. A motor accident left Richard Hanbury, founder and CEO of Sana Health UK Ltd, a paraplegic in excruciating pain. Doctors gave him five years to live due to severe pain from […]

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Exposure to arsenic, lead, copper and cadmium linked to increased risk of heart disease

Exposure to arsenic, lead, copper and cadmium is associated with an increased risk of cardiovascular disease and coronary heart disease, finds a comprehensive analysis of the evidence published by The BMJ today. In recent years, exposure to environmental toxic metals such as arsenic, lead, copper, and mercury have become a major global health concern. Arsenic and cadmium, for example, are […]

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Genetic susceptibility to lower vitamin D levels and calcium intake not linked to fracture

Having a genetic predisposition to lower vitamin D levels and calcium intake is not associated with an increased risk of osteoporotic fracture, conclude researchers in The BMJ today. Their findings add to the ongoing debate over the benefits for the general population of vitamin D supplementation, which is recommended by clinical guidelines to prevent fractures. The findings also back recent […]

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