Machine learning finds tumor gene variants and sensitivity to drugs in The Cancer Genome Atlas

Matching unique genetic information from cancer patients’ tumors with treatment options – an emerging area of precision medicine efforts – often fails to identify all patients who may respond to certain therapies. Other molecular information from patients may reveal these so-called “hidden responders,” according to a Penn Medicine study in Cell Reports this week. The findings are published alongside several […]

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Caregiving costs for heart disease and stroke survivors projected to soar to $128 billion by 2035

In a new analysis released today, the American Heart Association projects that the cost of informal caregiving for Americans with heart disease and stroke will more than double from $61 billion in 2015 to $128 billion by 2035. These new data on caregiving would increase the association’s predicted 2035 price tag for cardiovascular disease (CVD) total costs to $1.2 trillion […]

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Reducing severity of PTSD symptoms long-term holds significant public-health and economic implications

Both civilians and military veterans with post-traumatic stress disorder (PTSD) reap long-term benefits from psychotherapies used for short-term treatment, according to a new study from Case Western Reserve University. The findings suggest effective and lasting approaches for symptoms of PTSD—a debilitating and typically chronic disorder that rarely diminishes spontaneously and is associated with significant distress, impairment and considerable economic costs. […]

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Treating women subsistence farmers for intestinal worms improved fitness and could boost food production

A new study in the Democratic Republic of Congo (DRC) found that treating women subsistence farmers with just a single dose of a cheap deworming medication significantly improved their physical stamina for the grueling agriculture work needed for their family’s survival. The results of treatment could be twofold: improved health for farming women and increased food production by women who […]

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Researchers define target and mechanism of antibacterial drug fidaxomicin (Dificid)

A team of Rutgers University and international scientists has determined the molecular target and mechanism of the antibacterial drug fidaxomicin (trade name Dificid). Fidaxomicin was approved in 2011 for treatment of the CDC “urgent threat” bacterial pathogen Clostridium difficile (C. diff) and currently is one of two front-line drugs for treatment of C. diff. Fidaxomicin also exhibits potent antibacterial activity […]

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