Characterizing ‘keyhole’ is first step to fighting obesity at cellular level

Health Problems

An international team has uncovered the potential to beat obesity at the cellular level, characterizing for the first time a complex, little-understood receptor type that, when activated, shuts off hunger. Jens Meiler, professor of chemistry and pharmacology at Vanderbilt University, said pharmaceutical companies long have attempted to develop a small-molecule drug that could do just that. But until now, nobody […]

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Pathways in the young brain are associated with susceptibility for mental disorders

Health Problems

Adolescence is a period for individual growth and opportunities, but it also coincides with the emergence of many mental disorders. In a study that was recently published in JAMA Psychiatry, Norwegian researchers revealed that the pathways between brain regions are associated with early signs of mental illness in youth. The researchers analyzed a wide range of clinical, cognitive, and genetic […]

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Scientists discover sweet spot of activity in immune system key to fighting cancer

Health Problems

Scientists at the University of Southampton have shown how stimulating a specific location on the surface of immune cells can be targeted with antibodies to help in their fight against cancer. The new work concerns a receptor called CD40 found of the surface of certain immune cells which regulates their activity. The CD40 receptors are normally dispersed over the surface […]

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Scientists disconfirm belief that humans’ physiological reaction to emotions are uniform

Health Problems

How do you feel when you’re angry? Tense? Jittery? Exhausted? Is it the same every time? Is it identical to how your best friend, co-worker, or barista feel when they experience anger? In all likelihood the answer is no, that how you experience anger varies between situations, and that how you experience it varies from others. According to new research […]

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Efficient control of leukaemia with treatment by dual immune-checkpoint blockade

Health Problems

Chronic lymphocytic leukaemia (CLL) is a haematological malignancy that originates in the blood-forming cells of the bone marrow and spreads to other organs through the bloodstream. When infiltrating tissues, CLL cells come in contact with healthy cells, including immune cells. To ensure their survival and growth, CLL cells are able to establish a microenvironment in which the immune response is […]

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Metabolic syndrome common with chronic hep B infection

Health Problems

(HealthDay)—Metabolic syndrome (MetS) is prevalent among patients with chronic hepatitis B (HBV) infection, according to a study published online March 29 in Diabetes Care. Mandana Khalili, M.D., from the University of California, San Francisco, and colleagues assessed prevalence of MetS and its influence on alanine aminotransferase (ALT) levels and fibrosis among a multiethnic North American cohort with chronic HBV infection […]

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Studies show promise of immunotherapy combinations, including CAR T

Health Problems

As immunotherapies continue to make up a larger share of new cancer drugs, researchers are looking for the most effective ways to use these cutting edge treatments in combination with each or with other pre-existing options. New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy […]

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When others fail, new migraine treatment may work

Health Problems

People who have tried unsuccessfully to prevent migraine with other treatments may find relief with a drug called erenumab, according to a preliminary study released today that will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018. Migraine, which can be debilitating, is often very difficult to treat. As the […]

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