One-hour plasma glucose useful predictor of diabetic retinopathy

(HealthDay)—One- and two-hour plasma glucose concentrations (1h-PG and 2h-PG, respectively) are similarly effective at predicting diabetic retinopathy (DR), according to a study published online April 5 in Diabetes Care. Ethan Paddock, from the National Institutes of Health in Phoenix, and colleagues assessed the ability of 1h-PG and 2h-PG, derived from a 75-g oral glucose tolerance test (OGTT), to predict DR […]

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Drinking up to 3 cups of coffee per day may be safe, protective: study

Many clinicians advise patients with atrial or ventricular arrhythmias to avoid caffeinated beverages, but recent research has shown that coffee and tea are safe and can reduce the frequency of arrhythmias, according to a review published today in JACC: Clinical Electrophysiology. Arrhythmias, or abnormal heart rhythms, cause the heart to beat too fast, slow or unevenly. While some arrhythmias may […]

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Drug reduces size of some lung cancer tumors, relapse rate after surgery

A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients. The research teams at the Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, the Johns Hopkins Sidney Kimmel […]

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Cyberbullying, unmet medical needs contribute to depressive symptoms among sexual minority youth

Cyberbullying, dissatisfaction with family relationships, and unmet medical needs are major contributors to the high rates of depressive symptoms seen among adolescents who are gay, lesbian, bisexual or questioning their sexual orientation, according to researchers at the National Institutes of Health. Their new study on sexual minority youth now appears in Pediatrics. Researchers used data from the NEXT Generation Health […]

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Selective inhibitor shows early promise in patients with RET-altered cancers

BLU-667, a next-generation inhibitor that selectively targets the oncogenic receptor tyrosine kinase RET, was well tolerated and had broad clinical benefit in patients with advanced cancer that had progressed on previous therapies including multikinase inhibitor therapy. Proof-of-concept data will be presented from an ongoing phase I clinical trial at the AACR Annual Meeting 2018, April 14-18, in Chicago. “RET-altered cancers […]

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Painkillers in pregnancy may affect baby’s future fertility

Taking painkillers during pregnancy could affect the fertility of the unborn child in later life, research suggests. The study identifies that these drugs may also affect the fertility of future generations, by leaving marks on DNA. The findings add to a growing body of evidence that certain medicines, including paracetamol, should be used with caution during pregnancy. Researchers stress that […]

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New liquid biopsy-based cancer model reveals data on deadly lung cancer

Small cell lung cancer (SCLC) accounts for 14 percent of all lung cancers and is often rapidly resistant to chemotherapy resulting in poor clinical outcomes. Treatment has changed little for decades, but a study at The University of Texas MD Anderson Cancer Center offers a potential explanation for why the disease becomes chemoresistant, and a possible avenue to explore new […]

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First-in-human clinical trial of new targeted therapy drug reports promising responses for multiple

A phase I, first-in-human study led by The University of Texas MD Anderson Cancer Center reveals for the first time, an investigational drug that is effective and safe for patients with cancers caused by an alteration in the receptor tyrosine kinase known as RET. The drug appears to be promising as a potential therapy for RET-driven cancers, such as medullary […]

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