Heart-on-a-chip mimics drug response seen in humans

Researchers from TARA Biosystems, Inc. and GlaxoSmithKline (GSK) today published data demonstrating that TARA’s engineered heart-on-a-chip system replicated drug responses found in adult humans. The findings, published in the journal Toxicological Sciences, show TARA’s 3-D-cardiac tissue platform can predict how human hearts will respond to a wide range of drugs, something that has been a challenge in pre-clinical models until […]

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Scientists shed new light on how we perceive vibrations through touch

Researchers have demonstrated a universal decoding system in humans that determines how we perceive vibrations of different frequencies through touch. Their findings, published in eLife, suggest that this decoding system overrules our tactile sensory channels when we perceive vibrotactile stimuli. The system depends on neural discharge (or spike) patterns, regardless of the type of receptor that receives the stimuli, challenging […]

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Study: Racial tension may stem from fear of exposure to infectious diseases

Social scientists have long worked to understand the roots of racial prejudice in the U.S., and for years, the story went like this: As different groups are exposed to others, their prejudice against those others increases. Brian O’Shea wasn’t buying it. A postdoctoral fellow working in the lab of Matt Nock, the Edgar Pierce Professor of Psychology, O’Shea is the […]

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Brain reorganization predicts language production

The right hemisphere of the brain can take over language functions when the left hemisphere is damaged early in development, according to research in four-year-old children published in eNeuro. These findings offer insight into typical language development in children and the flexibility of the brain in response to injury. Language functions are typically localized in the left hemisphere of the […]

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Tiny blood cells could protect against cerebral palsy

Platelets—tiny cells critical for blood clotting—could be the key to protecting against brain damage occurring during pregnancy or around the time of birth. Information gained from the pre-clinical study led by Dr. Alison Farley and Dr. Samir Taoudi from the Walter and Eliza Hall Institute could enable doctors to intervene at the right time to prevent brain bleeds—a significant risk […]

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Injectable ‘bone spackling’: A cell therapy approach to heal complex fractures

Large, complex bone wounds are hard for doctors and patients alike to contend with. They often require grafts and multiple surgeries. Jan Stegemann, a University of Michigan professor of biomedical engineering, is reprogramming adult cells from bone marrow so that they can be injected directly into a wound and grow into bone. The marrow-derived cells are known as progenitor cells, […]

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Uncovering secrets of bone marrow cells and how they differentiate

Bone marrow contains biological factories, which pump out billions of new blood cells daily. The non-blood cells that maintain this production also have the potential to produce bone, fat and cartilage. This output all starts from stem cells that have the ability to differentiate into various types of cells. Knowledge of the genes that control this differentiation and the paths […]

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