Study finds how fat tissue shunts energy to tumors

Obesity is the second-leading preventable cause of cancer and represents one of the greatest threats to global human health. But it has not been clear exactly how whole-body metabolism affects tumor formation. In particular, the molecular mechanisms by which fat cells communicate with tumor tissue remain poorly understood.

Sanford Prebys Medical Discovery Institute (SBP) researchers recently addressed this question, revealing that inactivation of a protein called p62 in fat cells fuels aggressive, metastatic prostate cancer in mice. As reported in Cancer Cell, p62 deficiency triggers a shutdown of energy-consuming processes in fat tissue, thereby increasing the availability of nutrients for cancer cells.

“This work could lead to better therapies that consider cancer not just as a genetic or cellular disease, but as a whole-body process where tumors communicate with metabolic organs to maintain their unlimited appetite for nutrients,” says co-senior study author Maria Diaz-Meco, Ph.D., a professor in the Cancer Metabolism and Signaling Networks Program at SBP. “This is a vulnerability that can be targeted therapeutically.”

Diverting energy

Prostate cancer is the second-leading cause of cancer death among men in the United States, and obesity is a major risk factor for the progression and aggressiveness of this disease. But the underlying molecular mechanisms have remained unclear, in part due to the limitations of mouse models of obesity, which have not allowed researchers to study the specific crosstalk between fat cells and tumor tissue independently of dietary factors.

“Most of the studies addressing the role of adiposity and obesity in cancer use mice fed a high-fat diet,” says co-senior study author Jorge Moscat, Ph.D., director and professor of the Cancer Metabolism and Signaling Networks Program at SBP. “Although this mimics some of the situations in patients, it prevents a real understanding of the signaling pathways that control the bidirectional communication between tumors and adipocytes, or fat cells. This is essential if we want to identify therapeutic targets that can be harnessed to prevent the pro-tumorigenic signals emanating from the adipose tissue.”

To address this problem, Diaz-Meco and Moscat turned to a mouse model of obesity they previously helped to develop. These mice specifically lack p62 in fat cells, leading to increased adiposity and metabolic problems without altering food intake. In the new study, the researchers reveal a central role of p62 in fat tissue-tumor communication, which supports cancer metabolic fitness.

Specifically, they found that p62 deficiency in fat cells promotes the progression and metastasis of prostate cancer in mice by inhibiting a protein complex called mTORC1. The tumors suppress energy-consuming activities such as fat cell development, a metabolic process called oxidative phosphorylation, and fatty acid metabolism in white fat tissue. As a result, more fatty acids and other nutrients are available to support tumor growth. “This metabolic reprograming orchestrated by the loss of p62 in adipocytes appears to help tumors cope with the high-energy demands of an aggressive cancer,” Diaz-Meco says.

Additional experiments showed that p62 deficiency in fat tissue promotes the synthesis of proteins called osteopontin and Cpt1a, which are critical for prostate cancer proliferation, migration and invasion. These findings are clinically relevant because high levels of osteopontin and Cpt1a are associated with aggressive, metastatic castration-resistant prostate cancer in humans. “The significance is huge because we identify a new set of therapeutic targets that, if modulated, should block the ability of activated adipose tissue to promote tumor malignancy,” Moscat says.

Beyond genetics

According to the authors, the findings suggest that mTOR inhibitors currently used to treat a wide range of cancers may have the unintended consequence of shutting down fat tissue metabolism and fueling tumor growth, at least under certain circumstances. But this possibility needs to be evaluated in future studies. For their own part, the authors plan to further investigate the p62 signaling pathway in patients and identify druggable targets that could be evaluated for their therapeutic potential.

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