Proteins cooperate to break up energy structures in oxygen starved heart cells

During a heart attack, the supply of oxygen to heart cells is decreased. This reduced oxygen level, called hypoxia, causes the cell’s powerhouses, the mitochondria, to fragment, impairing cell function and leading to heart failure. Until now, few details have been known about how this process occurs. Researchers at the National Institute for Physiological Sciences, Japan, have revealed how filamin […]

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Impaired energy production may explain why brain is susceptible to age-related diseases

Defective energy production in old neurons might explain why our brains are so prone to age-related diseases. Salk researchers used a new method to discover that cells from older individuals had impaired mitochondria—the power stations of cells—and reduced energy production. A better understanding of the effects of aging on mitochondria could reveal more about the link between mitochondrial dysfunction and […]

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Study finds how fat tissue shunts energy to tumors

Obesity is the second-leading preventable cause of cancer and represents one of the greatest threats to global human health. But it has not been clear exactly how whole-body metabolism affects tumor formation. In particular, the molecular mechanisms by which fat cells communicate with tumor tissue remain poorly understood. Sanford Prebys Medical Discovery Institute (SBP) researchers recently addressed this question, revealing […]

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