Efficient control of leukaemia with treatment by dual immune-checkpoint blockade

Chronic lymphocytic leukaemia (CLL) is a haematological malignancy that originates in the blood-forming cells of the bone marrow and spreads to other organs through the bloodstream. When infiltrating tissues, CLL cells come in contact with healthy cells, including immune cells. To ensure their survival and growth, CLL cells are able to establish a microenvironment in which the immune response is […]

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‘Killer’ kidney cancers identified by studying their evolution

Scientists have discovered that kidney cancer follows distinct evolutionary paths, enabling them to detect whether a tumour will be aggressive and revealing that the first seeds of kidney cancer are sown as early as childhood. The three Cancer Research UK funded studies, published in the journal Cell, shed light on the fundamental principles of cancer evolution and could lead to […]

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Mouse study links early metastasis to systemic inflammation caused by wound healing

According to new research conducted in mice by Whitehead Institute scientists, surgery in breast cancer patients, which while often curative, may trigger a systemic immunosuppressive response, allowing the outgrowth of dormant cancer cells at distant sites whose ability to generate tumors had previously been kept in check by the immune system. Taking a non-steroidal anti-inflammatory drug (NSAID) around the time […]

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Caregiving costs for heart disease and stroke survivors projected to soar to $128 billion by 2035

In a new analysis released today, the American Heart Association projects that the cost of informal caregiving for Americans with heart disease and stroke will more than double from $61 billion in 2015 to $128 billion by 2035. These new data on caregiving would increase the association’s predicted 2035 price tag for cardiovascular disease (CVD) total costs to $1.2 trillion […]

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Relaxation response may reduce blood pressure by altering expression of a set of genes

High blood pressure—or hypertension—is a major risk factor for heart attack and stroke that affects as many as 100 million Americans and 1 billion people worldwide. Decades of research have demonstrated that the relaxation response—the physiological and psychological opposite of the well-known fight-or-flight stress response that can be achieved through relaxation techniques like yoga or mediation – can reduce blood […]

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