Brain science institute at Brown receives $100M gift

Brown University’s brain science institute has been given $100 million to advance the understanding of the brain and what causes Lou Gehrig’s Disease, Alzheimer’s and other neurodegenerative diseases. The Ivy League university in Providence, Rhode Island, announced the donation from alumnus Robert Carney and his wife, Nancy, on Wednesday. Institute Director Diane Lipscombe said she hopes the funding can be […]

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Many European countries are not ready to stop viral hepatitis

Many European countries lack a comprehensive policy to eliminate viral hepatitis as a major public health threat, according to a patient group-based survey implemented in 25 countries. The Hep-CORE study was coordinated by ISGlobal – an institution supported by the “la Caixa” Foundation – and led by the European Liver Patient’s Association. In 2016, viral hepatitis caused more deaths than […]

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Characterizing ‘keyhole’ is first step to fighting obesity at cellular level

An international team has uncovered the potential to beat obesity at the cellular level, characterizing for the first time a complex, little-understood receptor type that, when activated, shuts off hunger. Jens Meiler, professor of chemistry and pharmacology at Vanderbilt University, said pharmaceutical companies long have attempted to develop a small-molecule drug that could do just that. But until now, nobody […]

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Pathways in the young brain are associated with susceptibility for mental disorders

Adolescence is a period for individual growth and opportunities, but it also coincides with the emergence of many mental disorders. In a study that was recently published in JAMA Psychiatry, Norwegian researchers revealed that the pathways between brain regions are associated with early signs of mental illness in youth. The researchers analyzed a wide range of clinical, cognitive, and genetic […]

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Scientists discover sweet spot of activity in immune system key to fighting cancer

Scientists at the University of Southampton have shown how stimulating a specific location on the surface of immune cells can be targeted with antibodies to help in their fight against cancer. The new work concerns a receptor called CD40 found of the surface of certain immune cells which regulates their activity. The CD40 receptors are normally dispersed over the surface […]

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Scientists disconfirm belief that humans’ physiological reaction to emotions are uniform

How do you feel when you’re angry? Tense? Jittery? Exhausted? Is it the same every time? Is it identical to how your best friend, co-worker, or barista feel when they experience anger? In all likelihood the answer is no, that how you experience anger varies between situations, and that how you experience it varies from others. According to new research […]

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Efficient control of leukaemia with treatment by dual immune-checkpoint blockade

Chronic lymphocytic leukaemia (CLL) is a haematological malignancy that originates in the blood-forming cells of the bone marrow and spreads to other organs through the bloodstream. When infiltrating tissues, CLL cells come in contact with healthy cells, including immune cells. To ensure their survival and growth, CLL cells are able to establish a microenvironment in which the immune response is […]

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Metabolic syndrome common with chronic hep B infection

(HealthDay)—Metabolic syndrome (MetS) is prevalent among patients with chronic hepatitis B (HBV) infection, according to a study published online March 29 in Diabetes Care. Mandana Khalili, M.D., from the University of California, San Francisco, and colleagues assessed prevalence of MetS and its influence on alanine aminotransferase (ALT) levels and fibrosis among a multiethnic North American cohort with chronic HBV infection […]

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Studies show promise of immunotherapy combinations, including CAR T

As immunotherapies continue to make up a larger share of new cancer drugs, researchers are looking for the most effective ways to use these cutting edge treatments in combination with each or with other pre-existing options. New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy […]

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