New tools to boost the delivery of drugs to cancer tumours

The treatment of cancer tumours is made complex by their microenvironment and the abnormalities of the blood vessels sustaining them. The EU-funded NeoNaNo project has developed methods to improve drug delivery to tumours and improve the efficacy of anticancer therapy. Drug delivery to tumours is difficult. The blood vessels they depend on are abnormally structured, heterogeneously distributed and relatively poorly […]

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Virtual drug trials boost results

Bringing a new drug to market can cost more than two billion dollars. Not to mention years of work spent developing and testing for scientists, researchers, doctors, and trial participants. By bringing trials to the virtual realm, Belinda H. Tan ’96 has found a way to cut all that in half. Her company, Science 37, is moving the entire drug […]

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Infants exposed to hepatitis C increasing, yet not adequately screened, study finds

Due to the opioid epidemic, hepatitis C virus (HCV) is increasingamong pregnant women, resulting in a greater risk of perinatal transmission and HCV infection among children. Despite this increased prevalence, HCV-exposed infants are not adequately screened and many pediatric HCV infections remain undetected, according to a new study from researchers at Magee-Womens Research Institute (MWRI). The results are reported in […]

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Brick by brick—assembly of the measles virus

Researchers have been able to capture images of measles viruses as they emerge from infected cells, using state of the art cryo-electron tomography techniques. The new images will help with a greater understanding of measles and related viruses, and could give hints on antiviral drug strategies likely to work across multiple viruses of this type. The results were published Monday, […]

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FDA approves CAR T therapy for large B-cell lymphoma

The U.S. Food and Drug Administration (FDA) has expanded approval for a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, this time for the treatment of adult patients with relapsed or refractory large B-Cell lymphoma after two or more lines of systemic therapy. Today’s approval includes treatment of diffuse large B-cell lymphoma (DLBCL) – the most […]

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Formate prevents most folic acid-resistant neural tube defects in mice

Maternal folic acid supplementation has reduced the prevalence of neural tube defects, one of the most common structural malformations in people, by up to 80 percent. However, many infants are still born with a neural tube defect that appears to be resistant to folic acid supplementation. In this study, a multi-institutional research team has developed a novel folic acid-resistant neural […]

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Scientists identify two hormones that burn fat faster, prevent and reverse diabetes in mice

UCLA geneticists have created a new technique to hunt for hormones that influence how organs and tissues communicate with each other. The method enabled them to find naturally occurring molecules that play major roles in Type 2 diabetes, obesity and cardiovascular disease. In particular, they discovered: Two hormones called “notum” and “lipocalin-5” that speed up the body’s ability to burn […]

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