The Hut Group Swoops on Professional Skincare Retailer Dermstore.com

LONDON – England’s The Hut Group has snapped up specialist skincare retailer Dermstore.com for $350 million in cash, adding to its burgeoning portfolio of U.S. and international beauty brands. THG, which purchased Dermstore from Target Corp., described the company as “the number one pure-play online retailer in the U.S. of prestige skincare and specialty beauty brands.” The deal is subject […]

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Novel regulator of mitochondrial cell death reveals a promising target for cancer therapy

Researchers at The Wistar Institute have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target. They also found that expression of MFF is regulated by Myc, a ubiquitous mediator of cell proliferation that contributes to development of many cancer types. These results were published online in […]

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Researchers identify potential target for cardiac fibrosis treatment

A research team led by scientists from the Consortium for Fibrosis Research & Translation (CFReT) at the University of Colorado School of Medicine has identified a potential target for treating heart failure related to fibrosis. Fibrosis is a wound-healing response after tissue injury or stress. Cardiac fibrosis can cause abnormal stiffening of the heart, contributing to the pathogenesis of heart […]

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Researchers unveil experimental compound to block therapeutic target in blood cancer

Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer. They also developed an experimental therapeutic to block the signal and slow tumor growth. The researchers reported in the journal Proceedings of the National Academy of Sciences they identified a novel therapeutic target for primary effusion […]

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Study identifies new potential target in glioblastoma

Researchers are hopeful that new strategies could emerge for slowing the growth and recurrence of the most common primary brain cancer in adults, glioblastoma, based on the results of a study published today in Cancer Research. Research led by Toronto’s St. Michael’s Hospital and The Hospital for Sick Children (SickKids) suggests the protein ID1 is critical to tumour initiation and […]

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New target for drug intervention in Alzheimer’s disease identified

Scientists at the University of Alabama at Birmingham have identified an enzyme in the brain that may be an intriguing target for interventions against Alzheimer’s disease and other dementias. The researchers suggest that the enzyme, a serine/threonine kinase known as LIMK1, may play an important role in the degradation of dendritic spines, the connections between neurons in the brain. In […]

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Scientists uncover novel strategy to target common type of cancer

Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife. The findings, originally posted on bioRxiv, suggest that targeting a protein called Werner syndrome helicase (WRN) could represent a novel opportunity for treating a subgroup of cancer patients with microsatellite instability-high (MSI-H) tumors. MSI is a […]

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Engineered immune cells target broad range of pediatric solid tumors in mice

Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study from the Stanford University School of Medicine. The study, which will be published online Jan. 17 in Clinical Cancer Research, provides evidence that these engineered cells can target many types of pediatric solid tumors, including brain tumors. […]

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Protective effects of ADM-RAMP2 system make it a new therapeutic target for retinal vein occlusion

A clot in the retinal vein can lead to severe and irreversible loss of vision. In a report in the American Journal of Pathology investigators utilize a newly developed model of central retinal vein occlusion (CRVO) in mice that mimics many of the clinical features of CRVO in humans to study the pathologic effects of retinal occlusion and demonstrate the […]

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