Breaking the dogma: Key cell death regulator has more than one way to get the job done

Health Problems

Scientists at St. Jude Children’s Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted cells showing that more than one mechanism can trigger the process. The findings appeared online today in the Journal of Experimental Medicine. “Our findings break the existing dogma that RIPK1 kinase activity is required for […]

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Novel regulator of mitochondrial cell death reveals a promising target for cancer therapy

Health Problems

Researchers at The Wistar Institute have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target. They also found that expression of MFF is regulated by Myc, a ubiquitous mediator of cell proliferation that contributes to development of many cancer types. These results were published online in […]

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