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Two patients with the same kind of tumor can have very different experiences. One patient’s cancer may progress quickly while the other grows slowly. Treatments may shrink tumors or have no effect at all. And some patients survive while others don’t. Efforts to profile tumors at the DNA, RNA, or epigenetic levels have revealed subtypes of tumors that help oncologists […]
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Researchers at The University of Texas MD Anderson Cancer Center have shown how BRCA-associated protein 1 (BAP1) serves as a tumor suppressor gene in kidney, eye, bile duct, mesothelioma and other cancers by regulating a form of cell death called ferroptosis, opening up a potential new area of therapy research. Findings from the study, led by Boyi Gan, Ph.D., associate […]
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Increasing the amount of protein in the diet may reduce the liver’s fat content and lower the risk of diabetes in people with nonalcoholic fatty liver disease (NAFLD). The study is published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism. NAFLD—sometimes referred to as a “fatty liver”—occurs when more than 5 percent of the liver’s total weight […]
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Scientists have revealed that protein molecules in the brain are broken down and replaced at different rates, depending on where in the brain they are. The study, published in eLife, provides essential insights into how the components of different cells in the brain are altered. These kinds of alterations may be important in our abilities to learn and form memories, […]
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Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease. The multi-center Phase I trial, led by researchers at The University of Texas MD Anderson Cancer Center, was designed to determine ivosidenib’s safety and […]
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For middle-aged men, eating higher amounts of protein was associated with a slightly elevated risk for heart failure than those who ate less protein, according to new research in Circulation: Heart Failure, an American Heart Association journal. Despite the popularity of high protein diets, there is little research about how diets high in protein might impact men’s heart failure risk. […]
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One strategy for cancer therapy is to inhibit the development of blood vessels in the tumour. Researchers at Uppsala University show in a new study how the protein CD93 interacts with the protein network that is required for tumour vessels to form properly. Blocking this interaction could be used as a means to hamper blood vessel development and slow down […]
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Structural biologists at St. Jude Children’s Research Hospital have discovered how a key protein functions to trigger cell’s suicide machinery, called apoptosis. The scientists found that the protein, called BOK, is controlled separately from the rest of the apoptosis process—offering the potential for new drugs to more selectively kill cancer cells. Led by Tudor Moldoveanu, Ph.D., an assistant member of […]
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Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study, which will be published May 17 in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein […]
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A new study by CU School of Medicine researchers has determined that choices of protein intake from solid foods has a significant impact on infant growth during the first year of life. The study tested whether dairy-based or meat-based protein in an infant’s diet contributed to growth and weight gain. Sixty-four formula-fed infants were involved in the study, with the […]
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