Insulin Resistance and Parkinson's Disease

A growing pool of evidence suggests that Type 2 diabetes mellitus (T2DM) and Parkinson’s disease (PD) may share common pathological mechanisms, and that the presence of T2DM increases the risk of developing PD by 40%. Measuring blood sugar level. Image Credit: Neirfy / Shutterstock How is T2DM Connected to PD? PD, the second most common neurodegenerative disorder after Alzheimer’s disease, […]

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What is CRIA syndrome?

Skip to: Symptoms & Pathology Causes and Current Research Treatment Cleavage-resistant RIPK1-induced autoinflammatory (CRIA) syndrome, is a recently discovered autoinflammatory disease caused by mutations within the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) gene. The exact prevalence of CRIA syndrome is still undetermined as it has only recently been identified as a disease. Seven people from three separate families in the U.S. […]

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Identification of a key protein linked to ageing

Ageing is a dramatic public health issue in the face of the current demographic changes: the proportion of 60 and over in the world’s population will almost double by 2050. In this context, a new discovery has just broadened scientific knowledge. Researchers from the Developmental and Stem Cell Biology Department at the Institut Pasteur shed light on the mechanisms of […]

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Restoring protein homeostasis improves memory deficits in Down syndrome model

Down syndrome is the most common genetic cause of intellectual disability, and currently there is no effective treatment. Memory deficits are a hallmark of this condition and a study published today in the journal Science reports that the defects in a conserved stress pathway dubbed the ‘integrated stress response,’ or ISR, could explain the cognitive deficits in a mouse model […]

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Researchers identify protein that contributes to racial disparities in prostate cancer

Cancer researchers have long known that prostate cancer tends to be more common, more aggressive and more resistant to existing treatments in African-Americans than in Caucasian-Americans, but they’re only beginning to understand why. A Roswell Park Comprehensive Cancer Center study published today points to cellular factors that appear to be driving these disparities—mitochondrial differences that prevent formation of the cancer-killing […]

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Test detects protein associated with Alzheimer’s and CTE

An ultrasensitive test has been developed that detects a corrupted protein associated with Alzheimer’s disease and chronic traumatic encephalopathy (CTE), a condition found in athletes, military veterans, and others with a history of repetitive brain trauma. This advance could lead to early diagnosis of these conditions and open new research into how they originate, according to National Institutes of Health […]

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Suppression of DKK3 protein thwarts pancreatic tumor progression and prolongs survival

Researchers at The University of Texas MD Anderson Cancer Center have shed new light on why pancreatic tumors are so resistant to therapy. The answer may lie in treating a protein found in the scar-type tissue called stroma which often surrounds the tumors. The tumor-associated stroma is comprised mostly of pancreatic stellate cells (PSCs) and its density and possibly the […]

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Protein has unique effects in neural connections related to information processing

Our cognitive abilities come down to how well the connections, or synapses, between our brain cells transmit signals. A new study by researchers at MIT’s Picower Institute for Learning and Memory digs deep into the molecular mechanisms that enable synaptic transmission to show the distinct role of a protein that when mutated has been linked to causing intellectual disability. The […]

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