Study characterizes proteins resulting from RAS gene mutations, found in more than 20 percent of all human cancers

When a RAS gene operates normally, it acts as an on/off switch for cell signaling to control cell proliferation. But when the gene mutates, the switch jams into the “on” position, allowing cells to proliferate uncontrollably. This unstoppable cascade inevitably leads to cancer. “The mutation in the gene is very common in pancreatic and colon cancer,” said Neil Kelleher, the […]

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Music intensifies effects of anti-hypertensive medication

Researchers report that listening to music significantly enhances the effect of anti-hypertensive drugs. According to a study conducted by researchers on of São Paulo State University (UNESP) in Brazil and international collaborators, music intensifies the beneficial effects of medication a short time after it is taken to control high blood pressure. The results of the study were published in Scientific […]

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One-hour plasma glucose useful predictor of diabetic retinopathy

(HealthDay)—One- and two-hour plasma glucose concentrations (1h-PG and 2h-PG, respectively) are similarly effective at predicting diabetic retinopathy (DR), according to a study published online April 5 in Diabetes Care. Ethan Paddock, from the National Institutes of Health in Phoenix, and colleagues assessed the ability of 1h-PG and 2h-PG, derived from a 75-g oral glucose tolerance test (OGTT), to predict DR […]

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Drinking up to 3 cups of coffee per day may be safe, protective: study

Many clinicians advise patients with atrial or ventricular arrhythmias to avoid caffeinated beverages, but recent research has shown that coffee and tea are safe and can reduce the frequency of arrhythmias, according to a review published today in JACC: Clinical Electrophysiology. Arrhythmias, or abnormal heart rhythms, cause the heart to beat too fast, slow or unevenly. While some arrhythmias may […]

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Drug reduces size of some lung cancer tumors, relapse rate after surgery

A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients. The research teams at the Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, the Johns Hopkins Sidney Kimmel […]

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First-in-human clinical trial of new targeted therapy drug reports promising responses for multiple

A phase I, first-in-human study led by The University of Texas MD Anderson Cancer Center reveals for the first time, an investigational drug that is effective and safe for patients with cancers caused by an alteration in the receptor tyrosine kinase known as RET. The drug appears to be promising as a potential therapy for RET-driven cancers, such as medullary […]

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Art is in the eye of the beholder

A researcher from James Cook University in Australia has found that a person’s mental state affects how they look at art. JCU psychology lecturer Nicole Thomas said the same piece of artwork can attract admiration or rejection from different people. “One intuitive explanation is that personality and the way in which we visually examine artwork contributes to our preferences for […]

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Punjab, India: Mass treatment of a population with chronic hepatitis C infection produces high rates of cure

A large-scale study evaluating the feasibility of decentralized care and the provision of free direct-acting antiviral agents (DAAs) has reported high rates of cure among a population of almost 20,000 individuals completing treatment for hepatitis C virus (HCV) infection. The study conducted in Punjab, India, which was reported today at The International Liver Congress 2018 in Paris, France, validated the […]

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A third of bacterial infections in patients with cirrhosis across the world are multi-drug resistant

A worldwide study initiated to investigate the epidemiology and outcomes of bacterial infections in hospitalized patients with liver cirrhosis has reported a prevalence of multi-drug-resistant (MDR) bacteria of 34% and significant regional differences in the risk of developing a multi-drug-resistant infection. Research teams from 46 centres across the world collaborated in this international study, which was promoted by the International […]

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Anti-epileptic drugs increase the risk of bone fractures in children

New research has shown evidence that anti-epileptic drugs (AEDs) reduce bone density in children and therefore lead to an increase in the number of fractures, if used for more than a year. The study by the Murdoch Children’s Research Institute (MCRI), in conjunction with the Royal Melbourne Hospital (RMH), has prompted experts to highlight the importance of considering side effects […]

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