Study locates circadian clock that controls daily rhythms of aggression

Patients with Alzheimer’s disease and other forms of dementia commonly experience the sundown syndrome – a sudden worsening of confusion, agitation and aggression at the end of the day. Its daily pattern suggested that “sundowning,” as the phenomenon is also known, may be governed by the body’s internal biological clock. Synchronized by light and darkness, the circadian clock exerts control […]

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Study locates circadian clock that controls daily rhythms of aggression

Patients with Alzheimer’s disease and other forms of dementia commonly experience the sundown syndrome – a sudden worsening of confusion, agitation and aggression at the end of the day. Its daily pattern suggested that “sundowning,” as the phenomenon is also known, may be governed by the body’s internal biological clock. Synchronized by light and darkness, the circadian clock exerts control […]

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Index of tumor cells opens a new perspective to prevent cancer progression

Researchers from the School of Medicine in Ribeirão Preto (FMRP), at the University of São Paulo (USP), in collaboration with international groups, have developed indices that provide information about the prognosis of cancers, aid in the choice of the most appropriate therapy and identify potential targets for the development of new drugs. Their paper, titled “Machine Learning Identity Stemness Features […]

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New study highlights benefits of weekly nutrition classes to improve type 2 diabetes

Prescriptions are not enough—diet changes and nutrition education make the difference in people with diabetes, according to a study published in the Journal of the Academy of Nutrition and Dietetics. Researchers from the Physicians Committee for Responsible Medicine set up a study in a private endocrinology office in Washington, D.C. After working hours, the researchers put the waiting room chairs […]

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Telemedicine provides accurate diagnosis of rare cause of blindness in preemies

Accurately detecting a rare, but devastating cause of blindness in premature babies can be done as effectively with telemedicine as with traditional, in-person eye exams, a study published in JAMA Ophthalmology suggests. This is believed to be the first study to directly compare the two approaches. The finding could enable more blindness-preventing treatment for infants born in rural and other […]

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Massive single-cell survey of kidney cell types reveals new paths to disease

The kidney is a highly complex organ – far beyond a simple filter. Its function requires intricate interactions between many highly specialized cell types to extract waste, balances body fluids, form urine, regulate blood pressure, and secrete hormones. New research from a team in the Perelman School of Medicine at the University of Pennsylvania shines a light on specific cell […]

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Reducing severity of PTSD symptoms long-term holds significant public-health and economic implications

Both civilians and military veterans with post-traumatic stress disorder (PTSD) reap long-term benefits from psychotherapies used for short-term treatment, according to a new study from Case Western Reserve University. The findings suggest effective and lasting approaches for symptoms of PTSD—a debilitating and typically chronic disorder that rarely diminishes spontaneously and is associated with significant distress, impairment and considerable economic costs. […]

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In Europe, CHMP missed an opportunity for osteoporosis patients at high risk of fracture

Experts from the International Osteoporosis Foundation (IOF) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) regret the recent decision by the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) to reject the marketing application for abaloparatide, a potential new treatment option for postmenopausal women at high risk of […]

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Relaxation response may reduce blood pressure by altering expression of a set of genes

High blood pressure—or hypertension—is a major risk factor for heart attack and stroke that affects as many as 100 million Americans and 1 billion people worldwide. Decades of research have demonstrated that the relaxation response—the physiological and psychological opposite of the well-known fight-or-flight stress response that can be achieved through relaxation techniques like yoga or mediation – can reduce blood […]

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Researchers advise long-term monitoring of infants infected with Zika after birth

A collaborative research team led by Ann Chahroudi, MD, PhD, of Emory University is recommending long-term clinical monitoring for infants infected with Zika virus early after birth. The recommendation is based on the team’s research results showing for the first time that postnatal Zika virus infection of rhesus macaque infants results in persistent abnormalities in brain structure and function as […]

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