New technique predicts which melanoma patients are at risk for cancer recurrence, spread

For most patients, melanoma begins with a small, pigmented spot on their skin that they notice starts to change. Many primary melanomas can be cured by having this lesion removed, but melanoma can also recur and spread; an analysis of the removed lesion can offer some information on the likelihood that the cancer will come back. Today, lesions are analyzed […]

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New study finds evidence for reduced brain connections in schizophrenia

Advances in scanning have allowed researchers for the first time to show lower levels of a protein found in the connections between neurons in the living brains of people with schizophrenia. The researchers, who conducted the scans at the psychiatric imaging facility at the Medical Research Council (MRC) London Institute of Medical Sciences, say these changes could underlie the cognitive […]

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Study finds potential new treatment for preventing PTSD

Research led by the Centre for Addiction and Mental Health (CAMH) published in the Journal of Clinical Investigation points to a groundbreaking discovery about a new potential treatment and prevention for post-traumatic stress disorder (PTSD). The research team, led by Dr. Fang Liu, Senior Scientist and Head of Molecular Neuroscience in CAMH’s Campbell Family Mental Health Research Institute, and Professor […]

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Hikikomori: New definition helps identify, treat extreme social isolation

Experts in the Japanese phenomena of hikikomori say the condition of extreme social isolation is more widespread than previously acknowledged, and it deserves a clear and consistent definition to improve treatment across the globe. In an article published in the February issue of the journal World Psychiatry, experts cite a lack of broad clinical understanding of the condition. Although hikikomori […]

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New cellular player involved in obesity discover

The prevalence of obesity, a disease considered a serious public health problem, is increasing globally. In Portugal, almost half of the population is overweight and close to one million adults suffer from obesity. Known as a risk factor for the development of cardiovascular disease and diabetes, obesity is associated with chronic inflammation in fat tissues. New strategies to fight this […]

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New treatment strategy may thwart deadly brain tumors

Immune checkpoint inhibitors are important medications that boost the immune system’s response against certain cancers; however, they tend to be ineffective against glioblastoma, the most deadly primary brain tumor in adults. New research in mice led by investigators at Massachusetts General Hospital (MGH) and the University of Florida reveals a promising strategy that makes glioblastoma susceptible to these medications. The […]

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Type 1 diabetes: A new starting point to delay autoimmune response

Regulatory T cells (Tregs) prevent excessive immune reactions in healthy people. In the development of autoimmune type 1 diabetes, this protection is not sufficiently effective. Researchers at Helmholtz Zentrum München and LMU Munich have now deciphered a mechanism that impairs Treg differentiation and stability. In the study, when researchers inhibited the molecule that triggers this mechanism, an increased number of […]

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New assay assesses multiple cellular pathways at once

A novel technological approach developed by researchers at Baylor College of Medicine expands from two to six the number of molecular pathways that can be studied simultaneously in a cell sample with the dual luciferase assay, a type of testing method commonly used across biomedical fields. Published in the journal Nature Communications, the report shows that multiplexed hextuple luciferase assaying, […]

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Potential new cancer treatment a step closer

QIMR Berghofer researchers have discovered a potential new cancer immunotherapy target that involves switching off a regulatory cell to stop tumors growing and spreading. The study findings have been published today in Cancer Discovery, a journal of the American Association for Cancer Research. Senior researcher and head of QIMR Berghofer’s Cancer Immunoregulation and Immunotherapy Laboratory, Associate Professor Michele Teng, said […]

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New study provides insight into chronic kidney disease

Researchers have further analyzed a known signaling pathway they believe brings them one step closer to understanding the complex physiology of patients with chronic kidney disease (CKD), which might provide a path to new treatment options. CKD is a complex and unique condition that involves impaired removal of many different toxins from the blood. These toxins, which often are referred […]

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