FDA warns of liver problems for some taking hep C drugs

(HealthDay)—Taking the hepatitis C drugs Mavyret, Zepatier or Vosevi can trigger rare cases of severe liver problems or liver failure in patients who already have moderate-to-severe liver impairment, the U.S. Food and Drug Administration warned Wednesday. The agency has identified 63 cases of worsening liver function, some resulting in liver failure or death, among patients taking the drugs. While the […]

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Aspirin improves liver function after embolization of hepatocellular carcinoma

Aspirin therapy is associated with both improved liver function test results and survival after transarterial embolization (TAE) for hepatocellular carcinoma (HCC), according to an ahead-of-print article published in the September 2019 issue of the American Journal of Roentgenology (AJR). In a retrospective review of 304 patients led by F. Edward Boas at Memorial Sloan Kettering Cancer Center in New York […]

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Researchers tie metabolic enzyme to obesity and fatty liver disease

Researchers from Clemson University’s Environmental Toxicology Program have published research connecting an enzyme associated with detoxification to obesity and fatty liver disease, especially in males. William Baldwin, professor and graduate program coordinator in the College of Science’s department of biological sciences, and members of his laboratory used a novel mouse model developed in their laboratory to study the role of […]

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New therapy approach points to potential treatment of liver cancer patients with hepatitis B virus infection

Researchers from Duke-NUS Medical School, Singapore General Hospital (SGH) and Lion TCR have demonstrated that they were able to engineer HBV-specific T cells, a type of immune cells found in the body, to treat Hepatocellular carcinoma (HCC), a commonly occurring liver cancer. The treatment was also individualised, as T cells that were engineered were specific to the patients. The approach […]

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Results of early-stage liver cancer detection using liquid biopsy published

Today, Proceedings of the National Academy of Sciences (PNAS) published the results of a pilot study for early detection of liver cancer in a cohort of HBV carriers at risk for developing the disease. This screening technology, known as HCCscreen, relies on detecting a combination of tumor-specific mutations in cell free DNA (cfDNA) and protein markers. This work was a […]

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Higher intake of whole grains may lower risk for liver cancer

(HealthDay)—Higher intake of whole grains may be associated with a lower risk for hepatocellular carcinoma (HCC) among U.S. adults, according to a study published online Feb. 21 in JAMA Oncology. Wanshui Yang, Ph.D., from Anhui Medical University in Hefei, China, and colleagues assessed the associations between whole grain and dietary fiber (cereal, fruit, and vegetable) intake and the risk for […]

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Liver transplants double for alcohol-related liver disease

The proportion of U.S. liver transplants for alcohol-associated liver disease (ALD) has doubled in the last 15 years, in part due to broader acceptance of waiving the mandated period of sobriety before transplants for this population, according to a study by researchers at UC San Francisco. However, the study showed ongoing regional geographic variations in liver transplant rates for ALD […]

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Liver cancer patients can be treated for Hep C infection

A large, multi-center study refutes earlier suggestions that antiviral drugs for treating hepatitis C may lead to a higher recurrence of liver cancer. Researchers at UT Southwestern Medical Center studied the records of patients who had been successfully treated for liver cancer at 31 medical centers in North America, comparing those who were and were not given direct-acting antivirals for […]

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