leukemia Archives - Family Medicine News

Chemotherapy sometimes set the stage for drug-resistant leukemia at relapse

02.11.2019 Health Problems

Chemotherapy has helped make the most common childhood cancer one of the most curable, but researchers have evidence that the treatment may also prime some patients for relapse. Results published in the journal Blood reported that treatment-induced mutations cause drug resistance in some patients whose acute lymphoblastic leukemia (ALL) returns. “Our study reveals the evolution dynamics of pediatric ALL, which […]

Childhood leukemia cannot hide from the immune system

26.06.2019 Health Problems

St. Jude Children’s Research Hospital scientists have evidence that children with acute lymphoblastic leukemia mount a robust immune response to their cancer. The findings, which appear today in the journal Science Translational Medicine, will likely aid development of immunotherapy for the most common childhood cancer. Immunotherapy has revolutionized cancer treatment in the last decade, particularly for adults with melanoma, lung […]

Genetic variations in a fourth gene linked to elevated leukemia risk in Hispanic children

14.02.2019 Health Problems

St. Jude Children’s Research Hospital scientists have identified genetic variations in a fourth gene that are associated with an increased risk of acute lymphoblastic leukemia (ALL) in Hispanic children. The research appears today in the journal Blood. The gene is ERG, a transcription factor that is also mutated in the leukemic cells of some ALL patients. In this study, researchers […]

Obesity problem starts early phase of therapy in children with acute lymphoblastic leukemia

26.10.2018 Health Problems

Children with pediatric acute lymphoblastic leukemia (ALL) gain weight during treatment, and researchers at St. Jude Children’s Research Hospital have discovered that this problem starts during remission-induction treatment and suggests that early intervention should be considered. Chemotherapy drugs to treat ALL contribute to myriad problems, one of which is an increased risk of becoming overweight or obese. And because patients […]

Duvelisib has marked response, survival benefit in difficult-to-treat leukemia and lymphoma

05.10.2018 Health Problems

For some patients with difficult-to-treat leukemia and lymphoma, the investigational oral medicine duvelisib may significantly improve disease outcomes, according to phase III trial data published today in the journal Blood. The DUO trial studied the head-to-head comparison of duvelisib versus ofatumumab, an approved standard-of-care chemotherapy for relapsed or treatment-resistant chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). According to […]

Discovery could lead to better treatment for leukemia

09.08.2018 Health Problems

Previous research has revealed that patients with acute myeloid leukemia who also have a particular mutation in a gene called NPM1 have a higher rate of remission with chemotherapy. About one-third of leukemia patients possess this favorable mutation, but until now, how it helps improve outcomes has remained unknown. Scientists from the University of Illinois at Chicago report on how […]

Researchers map ‘family trees’ of acute myeloid leukemia

17.07.2018 Health Problems

For the first time, a team of international researchers has mapped the family trees of cancer cells in acute myeloid leukaemia (AML) to understand how this blood cancer responds to a new drug, enasidenib. The work also explains what happens when a patient stops responding to the treatment, providing important clues about how to combine enasidenib with other anti-cancer drugs […]

Study of acute myeloid leukemia patients shows protein inhibitor drug safe and effective with durable remissions

03.06.2018 Health Problems

Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease. The multi-center Phase I trial, led by researchers at The University of Texas MD Anderson Cancer Center, was designed to determine ivosidenib’s safety and […]

Chronic lymphocytic leukemia patient goes into remission thanks to single CAR T cell

30.05.2018 Health Problems

The doctors who have spent years studying the case call it “a series of fortunate events.” What began as a remarkable response to chimeric antigen receptor (CAR) T cell therapy is now providing evidence about the human genome and immune response that could help turn gene therapy non-responders into responders. Researchers at the University of Pennsylvania’s Abramson Cancer Center say […]

Single surface protein boosts multiple oncogenic pathways in acute myeloid leukemia

18.05.2018 Health Problems

Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study, which will be published May 17 in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein […]

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