Specialist technique used to study drugs completed for first time during Ebola outbreak

A specialist technique used to study drugs has been completed for the first time during an outbreak of Ebola virus disease. The study published today in eBiomedicine was a collaboration of researchers from Sierra Leone and the University’s of Glasgow, Oxford, Cambridge and the Liverpool School of Tropical Medicine. It used pharmacokinetics—the measurement of the change in drug concentration in […]

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New study finds evidence for reduced brain connections in schizophrenia

Advances in scanning have allowed researchers for the first time to show lower levels of a protein found in the connections between neurons in the living brains of people with schizophrenia. The researchers, who conducted the scans at the psychiatric imaging facility at the Medical Research Council (MRC) London Institute of Medical Sciences, say these changes could underlie the cognitive […]

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Study finds potential new treatment for preventing PTSD

Research led by the Centre for Addiction and Mental Health (CAMH) published in the Journal of Clinical Investigation points to a groundbreaking discovery about a new potential treatment and prevention for post-traumatic stress disorder (PTSD). The research team, led by Dr. Fang Liu, Senior Scientist and Head of Molecular Neuroscience in CAMH’s Campbell Family Mental Health Research Institute, and Professor […]

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Survivors of childhood cancers at risk for shortened life span

(HealthDay)—Survivors of childhood cancer remain at risk for shorter life spans, especially when they receive radiotherapy, according to a study published online Jan. 2 in JAMA Oncology. Jennifer M. Yeh, Ph.D., from the Harvard Medical School in Boston, and colleagues conducted a microsimulation model of competing mortality risks using data from the Childhood Cancer Survivor Study on five-year survivors of […]

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Obesity is a risk factor for cardiotoxicity in chemotherapy-treated patients with breast cancer

Anthracyclines remain a cornerstone of breast cancer therapy in combination with new-generation targeted drugs such as trastuzumab. Both types of drugs are major culprits in chemotherapy-induced heart disease. A recent study showed that being overweight or obese was a risk factor for cardiotoxicity in chemotherapy-treated patients with breast cancer, but it did not take into account related cardiac risk factors […]

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Researchers identify neurons responsible for rapid eye movements/REM during sleep

Rapid Eye Movement—not only the name of a successful American rock band, but also and not least a characteristic eye movement in paradoxical sleep, the stage with high dream activity. This sleep phase has a peculiarity: Although the muscle tone of the sleeping person is completely relaxed, the eyes suddenly move back and forth. The name “paradoxical sleep” is well […]

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CRISPR-Cas9 datasets analysis leads to largest genetic screen resource for cancer research

A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types. Scientists at the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard compared the consistency of the two datasets, independently verifying the methodology and findings. The […]

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Rates of depression and substance use higher for pregnant teens, study finds

Researchers from Lawson Health Research Institute and Brescia University College found that teenage pregnant women are more likely to live in poverty, have poorer mental health and have higher rates of substance use. There are limited Canadian studies on teenage pregnancies, in particular looking at risk factors and birth outcomes compared to women who became pregnant during adulthood. London researchers […]

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Promising findings for treating damaged heart valves

Aortic valve calcification is a challenging condition for the health service and for the patients concerned. The only treatment currently available is surgery. Mariia Boganova recently defended her thesis which addresses the options available for future pharmacological treatment. Mechanisms behind the disease The Russian doctoral research fellow explains that her thesis first looks at the mechanisms behind the disease. She […]

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