Deep brain stimulation eases Parkinson’s disease symptoms by boosting dopamine

In a new study of seven people with Parkinson’s disease, Johns Hopkins Medicine researchers report evidence that deep brain stimulation using electrical impulses jumpstarts the nerve cells that produce the chemical messenger dopamine to reduce tremors and muscle rigidity that are the hallmark of Parkinson’s disease, and increases feelings of well-being. “While deep brain stimulation has been used for treating […]

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Smart brain stimulators: Next-gen parkinson’s disease therapy

Researchers at the University of Houston have found neuro biomarkers for Parkinson’s disease that can help create the next generation of “smart” deep brain stimulators, able to respond to specific needs of Parkinson’s disease patients. Those with the disease often undergo the high-frequency brain stimulation, a well-established therapy for the progressive nervous system disorder that affects movement, but the therapy […]

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Researchers tie metabolic enzyme to obesity and fatty liver disease

Researchers from Clemson University’s Environmental Toxicology Program have published research connecting an enzyme associated with detoxification to obesity and fatty liver disease, especially in males. William Baldwin, professor and graduate program coordinator in the College of Science’s department of biological sciences, and members of his laboratory used a novel mouse model developed in their laboratory to study the role of […]

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Microvascular disease anywhere in the body may be linked to higher risk of leg amputations

Microvascular disease is independently associated with a higher risk of leg amputation compared to people without the disease, according to new research in the American Heart Association’s journal Circulation. The study, funded by the American Heart Association Strategically Focused Research Network in Vascular Disease and the U.S. Department of Veterans Affairs, examined amputation risk among people with microvascular disease or […]

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New target for drug intervention in Alzheimer’s disease identified

Scientists at the University of Alabama at Birmingham have identified an enzyme in the brain that may be an intriguing target for interventions against Alzheimer’s disease and other dementias. The researchers suggest that the enzyme, a serine/threonine kinase known as LIMK1, may play an important role in the degradation of dendritic spines, the connections between neurons in the brain. In […]

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ACA’s medicaid expansion may have lowered heart disease deaths

(HealthDay)—New research supports the notion that Obamacare has improved the health of Americans: State expansions in Medicaid appear to have cut the number of deaths from heart disease. Counties in states with expanded Medicaid experienced an average of four fewer deaths from heart disease per 100,000 people than states that didn’t accept the expansion under the Affordable Care Act. In […]

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FDA approves treatments for heart failure caused by rare disease

(HealthDay)—Vyndaqel (tafamidis meglumine) and Vyndamax (tafamidis) capsules have been approved to treat adults with cardiomyopathy caused by transthyretin mediated amyloidosis (ATTR-CM), the U.S. Food and Drug Administration announced today. Recommended dosage is four 20-mg capsules of Vyndaqel once daily or a single 61-mg capsule of Vyndamax once daily, according to the manufacturer. The two drugs, which are the first approved […]

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