Scientists uncover novel strategy to target common type of cancer

Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife. The findings, originally posted on bioRxiv, suggest that targeting a protein called Werner syndrome helicase (WRN) could represent a novel opportunity for treating a subgroup of cancer patients with microsatellite instability-high (MSI-H) tumors. MSI is a […]

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Cancer pain can be eased by palliative radiation therapy

Radiation therapy is, along with chemotherapy and surgery, one of the three main components of cancer treatment. It is often misunderstood and carries negative connotations. As radiation oncologists and assistant professors at Albert Einstein College of Medicine in New York and the University of British Columbia, we frequently work to dispel patients’ concerns about radiation —concerns that radiation treatment will […]

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Results of early-stage liver cancer detection using liquid biopsy published

Today, Proceedings of the National Academy of Sciences (PNAS) published the results of a pilot study for early detection of liver cancer in a cohort of HBV carriers at risk for developing the disease. This screening technology, known as HCCscreen, relies on detecting a combination of tumor-specific mutations in cell free DNA (cfDNA) and protein markers. This work was a […]

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Higher intake of whole grains may lower risk for liver cancer

(HealthDay)—Higher intake of whole grains may be associated with a lower risk for hepatocellular carcinoma (HCC) among U.S. adults, according to a study published online Feb. 21 in JAMA Oncology. Wanshui Yang, Ph.D., from Anhui Medical University in Hefei, China, and colleagues assessed the associations between whole grain and dietary fiber (cereal, fruit, and vegetable) intake and the risk for […]

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A new machine learning model can classify lung cancer slides at the pathologist level

Machine learning has improved dramatically in recent years and shown great promise in the field of medical image analysis. A team of research specialists at Dartmouth’s Norris Cotton Cancer Center have utilized machine learning capabilities to assist with the challenging task of grading tumor patterns and subtypes of lung adenocarcinoma, the most common form of the leading cause of cancer-related […]

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Inherited mutations may play a role in pancreatic cancer development

A small, retrospective study has found that, in patients with particular pancreatic duct lesions, the presence of an inherited mutation in a pancreatic cancer susceptibility gene may increase the patients’ risk of developing pancreatic cancer. To verify these results and learn more about the development of this deadly cancer, the researchers recommend more genetic studies. Their hope—in line with the […]

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New nanomedicines for a more efficient and less aggressive treatment of prostate cancer

In Europe, prostate cancer is the most common type of cancer among men with an incidence greater than 100 cases per 100,000 individuals. Furthermore, it is currently the second most common cause of cancer-related deaths among men. This pathology mainly affects elderly men: nine in 10 deaths take place after 65 years of age. Therefore, it represents a very serious […]

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Researchers identify protein that contributes to racial disparities in prostate cancer

Cancer researchers have long known that prostate cancer tends to be more common, more aggressive and more resistant to existing treatments in African-Americans than in Caucasian-Americans, but they’re only beginning to understand why. A Roswell Park Comprehensive Cancer Center study published today points to cellular factors that appear to be driving these disparities—mitochondrial differences that prevent formation of the cancer-killing […]

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