Largest-ever study of thyroid cancer genetics finds new mutations, suggests immunotherapy

University of Colorado Cancer Center researchers recently completed the largest-ever study of thyroid cancer genetics, mining the data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers. In addition to identification of specific genes that may drive these cancers and thus provide attractive targets for treatment, the researchers found that in several samples of advanced […]

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Radiotherapy offers new treatment option for liver cancer

A novel technique that delivers high doses of radiation to tumors while sparing the surrounding normal tissue shows promise as a curative treatment option for patients with early-stage liver cancer, according to a study published online in the journal Radiology. Curative treatment options for early-stage hepatocellular carcinoma (HCC), the most common type of liver cancer, include surgery, liver transplantation and […]

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A study links soil metals with cancer mortality

Spanish epidemiologists and geologists have found associations between esophageal cancer and soils where lead is abundant. Lung cancer has been associated with high copper content in soil; brain tumors are linked with areas rich in arsenic, and bladder cancer is associated with high cadmium levels. These statistical links do not indicate that there is a cause-effect relationship between soil type […]

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Shorter courses of prostate cancer radiotherapy are safe and effective

Radiotherapy given in high doses over a shorter period of time is safe and effective for prostate cancer patients, according to research presented at the ESTRO 37 conference today. The treatment, called ultrahypofractionated radiotherapy, involves hospital treatment every other day for two and half weeks, compared to every week day for eight weeks for standard radiotherapy. Researchers say this method […]

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Targeted radiotherapy for breast cancer offers good quality of life and fewer side effects

Quality of life for women treated with a more targeted radiotherapy treatment – called accelerated partial breast irradiation – is at least as good as quality of life for women treated with standard radiotherapy, according to research presented at the ESTRO 37 conference and published simultaneously in The Lancet Oncology. The treatment uses small tubes to deliver a higher dose […]

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Brachytherapy for cervical cancer does not increase the risk of ureteral stricture

A rare but potentially serious complication following radiation treatment for cervical cancer is a narrowing of the tube (the ureter) that takes urine from the kidneys to the bladder, which can lead to kidney damage and sometimes life-threatening infections. This is called ureteral stricture and, until now, there have been concerns that brachytherapy might increase the risk, although the treatment […]

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Mechanism that drives development of liver cancer brought on by non-alcoholic fatty liver disease discovered

A team of researchers from several institutions in China has found a mechanism that appears to drive the development of a type of liver cancer not caused by alcohol consumption. In their paper published in the journal Science Translational Medicine, the group describes their study of liver cancer in mouse models and what they found. Ngee Kiat Chua, Hudson Coates […]

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Scientists discover sweet spot of activity in immune system key to fighting cancer

Scientists at the University of Southampton have shown how stimulating a specific location on the surface of immune cells can be targeted with antibodies to help in their fight against cancer. The new work concerns a receptor called CD40 found of the surface of certain immune cells which regulates their activity. The CD40 receptors are normally dispersed over the surface […]

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Global ROS1 initiative: A patient-researcher collaboration targeting ROS1 cancer

Cancer patients have often organized support and informational groups around their disease types. Now a presentation at the American Association for Cancer Research (AACR) Annual Meeting 2018 describes the first research-focused group of patients organized around the genetic mutation that creates their cancer, namely changes to the gene ROS1. While “ROS1 fusion” has primarily been studied in lung cancer, the […]

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