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A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients. The research teams at the Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, the Johns Hopkins Sidney Kimmel […]
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For the first time, a treatment that boosts the immune system greatly improved survival in people newly diagnosed with the most common form of lung cancer. It’s the biggest win so far for immunotherapy, which has had much of its success until now in less common cancers. In the study, Merck’s Keytruda, given with standard chemotherapy, cut in half the […]
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Small cell lung cancer (SCLC) accounts for 14 percent of all lung cancers and is often rapidly resistant to chemotherapy resulting in poor clinical outcomes. Treatment has changed little for decades, but a study at The University of Texas MD Anderson Cancer Center offers a potential explanation for why the disease becomes chemoresistant, and a possible avenue to explore new […]
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University of Queensland researchers have developed a vaccine delivery technology that enables treatment to be tailored precisely for different cancers. UQ’s Professor Ranjeny Thomas said the technology had the potential to improve the precision of cancer immunotherapy, leading to better cancer outcomes and reduce harmful side-effects. “Flexible cancer vaccines are a long-sought treatment strategy in cancer immunotherapy,” Professor Thomas said. […]
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Physicians who received payment from pharmaceutical companies for meals, talks and travel were more likely to prescribe those companies’ drugs for two cancer types, a University of North Carolina Lineberger Comprehensive Cancer Center-led study has found. The study was published Monday in the Journal of the American Medical Association Internal Medicine. The preliminary findings were presented last year at the […]
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Matching unique genetic information from cancer patients’ tumors with treatment options – an emerging area of precision medicine efforts – often fails to identify all patients who may respond to certain therapies. Other molecular information from patients may reveal these so-called “hidden responders,” according to a Penn Medicine study in Cell Reports this week. The findings are published alongside several […]
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Physicians who received payment from pharmaceutical companies for meals, talks and travel were more likely to prescribe those companies’ drugs for two cancer types, a University of North Carolina Lineberger Comprehensive Cancer Center-led study has found. The study was published Monday in the Journal of the American Medical Association Internal Medicine. The preliminary findings were presented last year at the […]
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Researchers from the School of Medicine in Ribeirão Preto (FMRP), at the University of São Paulo (USP), in collaboration with international groups, have developed indices that provide information about the prognosis of cancers, aid in the choice of the most appropriate therapy and identify potential targets for the development of new drugs. Their paper, titled “Machine Learning Identity Stemness Features […]
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By combining data on pathology images of 13 types of cancer and correlating that with clinical and genomic data, a Stony Brook University-led team of researchers are able to identify tumor-infiltrating lymphocytes (TILs), called TIL maps, which will enable cancer specialists to generate tumor-immune information from routinely gathered pathology slides. Published in Cell Reports , the paper details how TIL […]
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Men on hormone therapy for prostate cancer may benefit significantly from hitting the gym with fellow patients and choosing more veggies and fewer cheeseburgers, a new study suggests. Androgen deprivation therapy is a powerful tool against prostate cancer, and more and more men are opting for the treatment as a growing array of hormone-based therapies become available. But it comes […]
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