Treating a rare genetic disorder that causes colon cancer in children

A University of Houston pharmaceutical scientist is developing a new drug which could bring relief to children suffering with Familial Adenomatous Polyposis (FAP), a rare genetic disorder characterized by hundreds—if not thousands—of colorectal polyps. This hereditary cancer predisposition syndrome occurs in 3-per-100,000 live births and, if left untreated, causes colorectal cancer in patients nearly 100 percent of the time. Prior […]

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Genetic ‘whodunnit’ for cancer gene solved

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the long-standing mystery around why AMPK can both hinder and help cancer. The lab of Salk Professor Reuben Shaw showed that late-stage cancers can trigger AMPK’s cellular recycling signal to cannibalize pieces […]

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Experts call for a targeted approach to cancer prevention

Policymakers around the world should consider introducing more targeted early interventions in a bid to tackle cancer, according to experts at the University of Stirling. A new paper – published in the International Journal of Healthcare Policy – analysed data from 162 countries to examine the relationship between economic growth and cancer incidence. Dr. Bryan McIntosh, of the Faculty of […]

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Potential markers identified for early detection and prevention of liver cancer

Liver cancer is the second leading cause of cancer-related mortality worldwide, claiming 700,000 lives each year. Most cases are discovered too late for a cure—but now a study offers hope of early detection, and targets for new treatments. Published in Frontiers in Cell and Developmental Biology, the results show a dramatic increase in expression of sugar-burning ‘glycolytic’ enzymes in precancerous […]

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Innovations in ultrasound imaging improve breast cancer detection

A new ultrasound technique can help distinguish benign breast tumours from malignant ones. The technology was developed with support from the Swiss National Science Foundation. Ultrasound is one of the three main technologies used in medical imaging. It is more compact and affordable than nuclear magnetic resonance imaging (MRI) techniques, and safer than x-rays. But the images it produces are […]

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Head and neck cancer survivors at increased risk of suicide

Despite improved survival rates among cancer patients, the risk of death by suicide remains high, especially among those treated for head and neck cancers. The findings, by Nosayaba Osazuwa-Peters, BDS, PH.D., MPH, assistant professor of otolaryngology at Saint Louis University School of Medicine and faculty member at the Saint Louis University Cancer Center, were published in the latest issue of […]

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Study identifies link between DNA-protein binding, cancer onset

Researchers at the Stanford University School of Medicine and their collaborators at other institutions have identified a link between how proteins bind to our DNA and how cancer develops. This finding may allow researchers to predict cancer pathways and long-term patient outcomes. The research focuses on chromatin, the DNA-protein complex where all genes reside. Specifically, it evaluates chromatin’s relationship to […]

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Radiation/cisplatin combination established as standard of care for HPV+ oral cancer

Combinations of radiation and chemotherapy drugs have been shown to cure HPV-related head and neck cancer with a high success rate. A new phase III trial has now determined that cisplatin chemotherapy, combined with radiation therapy, produces the best results and should be considered the standard of care. Findings will be presented today at the 60th Annual Meeting of the […]

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Major response to immunotherapy in early-stage mismatch repair deficient colon cancer

Pre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major pathological responses in 100 percent of early-stage colon cancers with mismatch repair deficiencies, according to results reported at ESMO 2018 from the first exploratory phase II trial to investigate this approach. Restoring patients’ immune response against cancer cells with checkpoint inhibitors is an established treatment […]

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