Mavyret approved as 8-week treatment for hep C, compensated cirrhosis

(HealthDay)—Approval of Mavyret (glecaprevir and pibrentasvir) tablets has been expanded to eight-week treatment for treatment-naive patients aged 12 years and older with chronic hepatitis C virus (HCV) genotypes 1 through 6 and compensated cirrhosis, the U.S. Food and Drug Administration announced last week. Mavyret is the first eight-week treatment approved for any treatment-naive HCV patients, regardless of cirrhosis status or […]

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FDA warns of liver problems for some taking hep C drugs

(HealthDay)—Taking the hepatitis C drugs Mavyret, Zepatier or Vosevi can trigger rare cases of severe liver problems or liver failure in patients who already have moderate-to-severe liver impairment, the U.S. Food and Drug Administration warned Wednesday. The agency has identified 63 cases of worsening liver function, some resulting in liver failure or death, among patients taking the drugs. While the […]

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Liver cancer patients can be treated for Hep C infection

A large, multi-center study refutes earlier suggestions that antiviral drugs for treating hepatitis C may lead to a higher recurrence of liver cancer. Researchers at UT Southwestern Medical Center studied the records of patients who had been successfully treated for liver cancer at 31 medical centers in North America, comparing those who were and were not given direct-acting antivirals for […]

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Canada updates guidelines for hepatitis C virus infection

(HealthDay)—A guideline published in the June 4 issue of CMAJ, the journal of the Canadian Medical Association, provides updated evidence-based recommendations for the treatment of patients with chronic hepatitis C virus (HCV) infection. Hemant Shah, M.D., from the University of Toronto, and colleagues conducted a focused literature search to update the evidence base used in the 2015 guideline. The resulting […]

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Insurance denials for new hepatitis C drugs remain high nationwide, study suggests

Highly effective drugs that can cure chronic hepatitis C infection in approximately 95 percent of patients first became available in the U.S. in 2014. But both public and private insurers continue to deny coverage for these costly drugs at high rates nationwide, despite efforts to remove treatment restrictions, according to a new study published in Open Forum Infectious Diseases. The […]

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Infants exposed to hepatitis C increasing, yet not adequately screened, study finds

Due to the opioid epidemic, hepatitis C virus (HCV) is increasingamong pregnant women, resulting in a greater risk of perinatal transmission and HCV infection among children. Despite this increased prevalence, HCV-exposed infants are not adequately screened and many pediatric HCV infections remain undetected, according to a new study from researchers at Magee-Womens Research Institute (MWRI). The results are reported in […]

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