CRISPR-Cas9 datasets analysis leads to largest genetic screen resource for cancer research

A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types. Scientists at the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard compared the consistency of the two datasets, independently verifying the methodology and findings. The […]

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Artificial intelligence can now predict long-term risks of heart attack and cardiac death

A new study in Cardiovascular Research finds that machine learning, the patterns and inferences computers use to learn to perform tasks, can predict the long-term risk of heart attack and cardiac death. Indeed, machine learning appears to be better at predicting heart attacks and cardiac deaths than the standard clinical risk assessment used by cardiologists. Researchers here studied subjects from […]

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Type 1 diabetes: A new starting point to delay autoimmune response

Regulatory T cells (Tregs) prevent excessive immune reactions in healthy people. In the development of autoimmune type 1 diabetes, this protection is not sufficiently effective. Researchers at Helmholtz Zentrum München and LMU Munich have now deciphered a mechanism that impairs Treg differentiation and stability. In the study, when researchers inhibited the molecule that triggers this mechanism, an increased number of […]

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Study: Obesity could affect brain development in children

Published studies have long found a correlation between obesity in children and decreased executive function. New research published in JAMA Pediatrics, based on data mined from a massive national research study, suggests that a change in brain structure—a thinner prefrontal cortex—may help explain that interrelationship. “Our results show an important connection; that kids with higher BMI tend to have a […]

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Rates of depression and substance use higher for pregnant teens, study finds

Researchers from Lawson Health Research Institute and Brescia University College found that teenage pregnant women are more likely to live in poverty, have poorer mental health and have higher rates of substance use. There are limited Canadian studies on teenage pregnancies, in particular looking at risk factors and birth outcomes compared to women who became pregnant during adulthood. London researchers […]

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Novel genetic signature that can predict some kinds of breast cancer is identified

Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases. The research, published in the journal PLOS Genetics, combined a study of the genes involved in retinopathy, […]

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