Antibodies linked to heart attacks

Levels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoimmune co-morbidity, a study from Karolinska Institutet in Sweden published in Annals of Internal Medicine reports.

Antiphospholipid antibodies (aPL) are a group of antibodies that target endogenous tissue, including the fat molecule cardiolipin and the plasma protein β2glycoprotein-I. Cardiolipin is found in the membranes of blood vessel and blood platelet cells, whereas β2glycoprotein-I is found in the blood and is thought to help the body rid itself of dead cells.

The antibodies are common in rheumatic diseases such as SLE and increase the risk of blood clots. Antiphospholipid syndrome (APS) is an autoimmune condition characterised by recurrent blood clots and/or pregnancy morbidities together with chronically elevated levels of antiphospholipid antibodies.

It is unknown how common the antibodies are in patients with myocardial infarction but without any autoimmune co-morbidity. Previous studies have been small and the antibody measurement flawed.

“I’ve long been convinced that the antibodies are more common than we think, and have now been able to analyse their presence in a large patient population,” says Elisabet Svenungsson, professor of rheumatology at Karolinska Institutet’s Department of Medicine in Solna.

The study involved 800 patients from 17 Swedish hospitals who had suffered their first myocardial infarction and as many matched healthy controls. Their blood was then analysed six to 10 weeks after the infarction for three different antiphospholipid antibody types: immunoglobulin G (IgG), M (IgM) and A (IgA). It was found that 11 percent of the patients had antiphospholipid antibodies against both cardiolipin and β2glycoprotein-I, which was 10 times more than the controls.

“It was a surprisingly high proportion of the patients, and the levels were also clearly high,” says Professor Svenungsson. However, the increase was only found in the IgG antibodies, the type that is considered most associated with blood clots.

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