Liver cancer cell ‘switch’ found that could improve future therapies

Imperial researchers have found a new cell mechanism that could be used to target tumours in the future. The newly discovered ‘switch’ controls the activity of two proteins – ‘deleted in liver cancer-1’ (DLC1), a tumour suppressor, and talin. Both proteins control whether or not cancer cells spread to other parts of the body, but the exact mechanisms have remained […]

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Fewer dialysis patients facing leg amputations

(HealthDay)—Losing a leg is one of the most traumatic consequences of advanced kidney disease, but the risk of amputations has dropped significantly since 2000, a new study finds. Between 2000 and 2014, amputations among U.S. patients with end-stage kidney disease who were receiving dialysis were cut by 51 percent. Despite the decrease, however, almost half of patients who had amputations […]

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Lack of a single molecule may indicate severe and treatment-resistant depression

People with depression have low blood levels of a substance called acetyl-L-carnitine, according to a Stanford University School of Medicine scientist and her collaborators in a multicenter study. Naturally produced in the body, acetyl-L-carnitine is also widely available in drugstores, supermarkets and health food catalogs as a nutritional supplement. People with severe or treatment-resistant depression, or whose bouts of depression […]

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No higher risk of autoimmune disorders after HPV4 vaccination

(HealthDay)—Following quadrivalent human papillomavirus (HPV4) vaccination, girls age 12 to 17 years do not have increased risk of autoimmune disorders, according to a study published recently in CMAJ, the journal of the Canadian Medical Association. Erin Y. Liu, from Queen’s University in Kingston, Canada, and colleagues conducted a population-based retrospective cohort study using Ontario’s administrative health and vaccination databases from […]

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Inflammation inhibitor delivered directly to kidneys reverses course of destructive nephritis

Using a manmade version of a human antibody to directly deliver a drug that inhibits a powerful driver of inflammation, can reverse a disease course that often leads to kidney failure and dialysis, investigators report. They have additionally found that it’s the powerhouses of kidney cells, called mitochondria, that are particularly impacted by the acute or chronic inflammation called nephritis, […]

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Canada updates guidelines for hepatitis C virus infection

(HealthDay)—A guideline published in the June 4 issue of CMAJ, the journal of the Canadian Medical Association, provides updated evidence-based recommendations for the treatment of patients with chronic hepatitis C virus (HCV) infection. Hemant Shah, M.D., from the University of Toronto, and colleagues conducted a focused literature search to update the evidence base used in the 2015 guideline. The resulting […]

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Stent retriever thrombectomy effective for longer window after stroke

A new study shows promising real-world outcomes for patients receiving a stent retriever thrombectomy six hours after they experience an acute ischemic stroke (AIS). The study was presented today at the Society of NeuroInterventional Surgery’s (SNIS) 15th Annual Meeting. Real-World Stent Retriever Thrombectomy for Acute Ischemic Stroke Beyond 6 Hours of Onset: Analysis of the Combined NASA and TRACK Registries […]

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Rewriting our understanding of gastric tumors

The immune system can be an important ally in the fight against cancer. A study from McGill scientists published today in Science suggests that the reverse may also be true—that abnormal inflammation triggered by the immune system may underlie the development of stomach tumours in patients with a hereditary cancer syndrome known as Peutz-Jeghers Syndrome (PJS). The findings are likely […]

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Traumatic brain injury: Discovery of two molecules could lead to new drug treatments

After 10 years of research, a Rutgers-led team of scientists has identified two molecules that protect nerve cells after a traumatic brain injury and could lead to new drug treatments. The molecules promote full recovery after traumatic brain injury (TBI) in mice, according to the study published online in Neurobiology of Disease. Traumatic brain injury is the leading cause of […]

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