First in-depth profile of CAR T-cell signals suggests how to improve immunotherapy

CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses have not been thoroughly examined. Understanding these pathways is important for designing future generations of CAR T-cell therapies, including reducing side effects, preventing […]

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Button batteries kill—here’s how we can prevent needless child deaths from battery ingestion

In 2013, four-year-old Summer Steer died from acute blood loss several days after swallowing a button battery. She hadn’t told her family she’d swallowed anything, so they didn’t know what was wrong. At least not until the caustic reaction caused by the battery, which had lodged in her oesophagus, ate through to her aorta. She presented to hospital with a […]

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Study provides insight into how dying neurons control eating behaviors of the brain microglia

A new Mount Sinai study, published July 23 in the journal Nature Neuroscience, provides important insight into how microglia, cells that form a branch of the immune system inside the brain, go about their job of clearing out dying and non-functional neurons—and how they sometimes mistakenly attack healthy neurons, an event that can play a role in neurodegenerative diseases like […]

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Science Says: How family separation may affect kids’ brains

Doctors have long known that separating families and other traumatic events can damage children’s well-being. More recent research has shed some light on how that may happen: Severe early adversity may cause brain changes and “toxic stress,” resulting in lasting psychological and physical health problems. A “zero-tolerance” immigration policy announced this spring by the Trump Administration has separated 2,300 children […]

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