Humans more unique than expected when it comes to digesting fatty meals

People have very individualized inflammatory responses to eating a high-fat meal. These were the somewhat unexpected results of a study recently published in the Journal of Nutritional Biochemistry by researchers at the Agricultural Research Service (ARS) and their University of California-Davis colleagues. “We looked at the inflammatory reactions of 20 volunteers at 0, 3 and 6 hours after eating a […]

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Loss of a DNA repair system creates a unique vulnerability in many cancer types

Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes’ activity, in the process becoming dependent on those genes for their survival and growth. The resulting genetic dependencies may provide targets for developing new precision-guided drugs or other cancer treatment strategies. Reporting in Nature, researchers led by members of the Cancer Dependency […]

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Protein has unique effects in neural connections related to information processing

Our cognitive abilities come down to how well the connections, or synapses, between our brain cells transmit signals. A new study by researchers at MIT’s Picower Institute for Learning and Memory digs deep into the molecular mechanisms that enable synaptic transmission to show the distinct role of a protein that when mutated has been linked to causing intellectual disability. The […]

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Unique mechanism of action inhibiting paracellular phosphate absorption

Ardelyx, Inc. today announced that the novel mechanism of action for tenapanor for the treatment of hyperphosphatemia, or elevated serum phosphorus, has been published in the peer-reviewed journal Science Translational Medicine. Tenapanor is a sodium/hydrogen exchanger 3 (NHE3) inhibitor currently being evaluated in a second Phase 3 registration trial, the PHREEDOM trial, for the treatment of hyperphosphatemia in patients with […]

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