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A new study helps to explain the mechanism by which pancreatic cells secrete high levels of insulin during the early stages of diabetes. A central question in diabetes research is why cells of the pancreas, known as beta cells, initially over-secrete insulin. The prevailing theory was that the body may be in the process of becoming “deaf” to insulin, so […]
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Regulatory T cells (Tregs) prevent excessive immune reactions in healthy people. In the development of autoimmune type 1 diabetes, this protection is not sufficiently effective. Researchers at Helmholtz Zentrum München and LMU Munich have now deciphered a mechanism that impairs Treg differentiation and stability. In the study, when researchers inhibited the molecule that triggers this mechanism, an increased number of […]
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It is a generally accepted idea that good aerobic fitness reduces the risk of type 2 diabetes, and it has also been thought to protect against other obesity-induced adverse changes in the glucose metabolism. However, this idea is based on studies whose methodology does not allow a distinction between the roles of aerobic fitness and body fat percentage as risk […]
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Scientists from the School of Medicine, Trinity College Dublin, have, for the first time, discovered a family of proteins that are associated with lower blood sugar levels among obese patients with type 2 diabetes. Their research is published today in the international journal Nature Communications. The study showed that patients with type 2 diabetes who have high levels of the […]
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A new study shows that type 2 diabetes in midlife is associated with a 30% increased risk of a serious blockage of the brain arteries, often leading to stroke, and a doubling of the risk of narrowing of the brain’s arteries in people over 60 years. The research is based on a cohort of twins in Sweden and published in […]
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Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife. The findings, originally posted on bioRxiv, suggest that targeting a protein called Werner syndrome helicase (WRN) could represent a novel opportunity for treating a subgroup of cancer patients with microsatellite instability-high (MSI-H) tumors. MSI is a […]
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A team of researchers affiliated with multiple institutions across Germany has discovered a new type of blood vessel in mouse bones. In their paper published in the journal Nature Metabolism, the group describes making sample mouse bones transparent, as well as their microscopic properties. Christopher Ritchlin and Iannis Adamopoulos with the University of Rochester and the University of California, respectively, […]
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By blocking a protein, VDAC1, in the insulin-producing beta cells, it is possible to restore their normal function in case of type 2 diabetes. In preclinical experiments, the researchers behind a new study have also shown that it is possible to prevent the development of the disease. The findings are published in the scientific journal Cell Metabolism. The researchers at […]
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(HealthDay)—Type 2 diabetes is associated with an increased risk of developing cancer and dying from certain forms of the disease, a new study suggests. However, the researchers noted, the absolute increased risk is low. “Our findings do not suggest that everyone who has diabetes will go on to develop cancer in later life,” said study leader Hulda Hrund Bjornsdottir, from […]
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A new computer program can analyze images of patients’ lung tumors, specify cancer types, and even identify altered genes driving abnormal cell growth, a new study shows. Led by researchers at NYU School of Medicine and published online in Nature Medicine, the study found that a type of artificial intelligence (AI), or “machine learning” program, could distinguish with 97 percent […]
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