Mouse study mirrors human findings that link chemotherapy and APOE4 to cognitive issues

The research, led by Georgetown University Medical Center (GUMC) investigators and published in Neurotoxicity Research, complements findings from another GUMC-led study, published Oct. 3, that found a subset of breast cancer patients who experience long lasting cognitive deficits also have the APOE4 gene. Cancer survivors often report memory difficulties and this study, published in the Journal of Clinical Oncology (JCO), […]

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AI could predict cognitive decline leading to Alzheimer’s disease in the next five years

A team of scientists has successfully trained a new artificial intelligence (AI) algorithm to make accurate predictions regarding cognitive decline leading to Alzheimer’s disease. Dr. Mallar Chakravarty, a computational neuroscientist at the Douglas Mental Health University Institute, and his colleagues from the University of Toronto and the Centre for Addiction and Mental Health, designed an algorithm that learns signatures from […]

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Phage therapy draws renewed interest to combat drug-resistant microbes

The married professors were spending their Thanksgiving holiday in Egypt when the husband, Thomas L. Patterson, Ph.D., got very sick very quickly, experiencing fever, nausea and a racing heartbeat. By the time Patterson was accurately diagnosed with a highly multi-drug resistant bacterial infection, he was near death. His wife, Steffanie Strathdee, Ph.D., promised to “leave no stone unturned.’” What happened […]

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Family history linked to early-onset A-fib in minorities

(HealthDay)—Probands of African or Hispanic/Latino descent with early-onset atrial fibrillation (EOAF) are more likely than European Americans to have a first-degree relative with AF, according to a study published online Sept. 21 in JAMA Network Open. Zain Alzahrani, M.D., from the University of Illinois at Chicago, and colleagues conducted a cohort study to examine the role of family history in […]

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Study: Improvement in glycemic parameters by adding dapagliflozin to metformin in T2D

Researchers used continuous glucose monitoring (CGM) to assess the effects of adding dapagliflozin to a regimen of either metformin or insulin in patients with type 2 diabetes (T2D) and found significant reductions in mean glucose and other glycemic factors, with greater improvements seen in patients taking metformin compared to insulin. The design and results of this trial are published in […]

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Doctors issue caution over missed cancer diagnoses tied to immune disorder

Physicians who specialize in a devastating and aggressive immune disorder called hemophagocytic lymphohistiocytosis (HLH) report in a new study that extra care should be taken to ensure an HLH diagnosis doesn’t obscure possible underlying cancers. Because HLH is dangerously aggressive in its progression and attack on vital organs—often causing death—doctors frequently pursue immediate treatment for the immune disorder after a […]

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Can we teach heart cells to grow up?

Scientists around the world have been trying to replace damaged heart tissue using lab-made heart-muscle cells (cardiomyocytes), either injecting them into the heart or applying patches laced with the cells. But results to date have been underwhelming. “If you make cardiomyocytes in a dish from pluripotent stem cells, they will engraft in the heart and form muscle,” says William Pu, MD, […]

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Media violence, impulsivity and family conflict tied to aggressive behaviors in teenagers

Teenagers exposed to TV and film violence and high levels of household conflict are at risk of engaging in aggressive behaviors, according to a new study by researchers at three U.S. universities. Especially prone to aggressive tendencies are those who also have high levels of impulsivity, the six-member research team reported in a study published online ahead of print in […]

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