Thrombospondin-1 may serve as a potential therapeutic target for thoracic aortic aneurysms

Researchers at the University of Tsukuba and Kansai Medical University in Japan reveal matricellular protein Thrombospondin-1 (Thbs1) contributes to the development of aortic aneurysm in mice and humans. The thoracic aorta is constantly exposed to mechanical forces generated by heart contraction and blood flow. Thoracic aortic aneurysms (TAAs) are life-threatening diseases defined as a permanent abnormal dilatation of the thoracic […]

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