New technique predicts which melanoma patients are at risk for cancer recurrence, spread

For most patients, melanoma begins with a small, pigmented spot on their skin that they notice starts to change. Many primary melanomas can be cured by having this lesion removed, but melanoma can also recur and spread; an analysis of the removed lesion can offer some information on the likelihood that the cancer will come back. Today, lesions are analyzed […]

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Loss of function in key Y-chromosome genes increases cancer risk in men

Numerous studies have shown that men are more susceptible to cancer than women; however, the reason for this difference remains poorly understood. A new study by researchers from the Barcelona Institute for Global Health (ISGlobal) has identified a key biological mechanism that puts men at higher risk of cancer: loss of function in certain genes of the sex-determining Y chromosome. […]

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Survivors of childhood cancers at risk for shortened life span

(HealthDay)—Survivors of childhood cancer remain at risk for shorter life spans, especially when they receive radiotherapy, according to a study published online Jan. 2 in JAMA Oncology. Jennifer M. Yeh, Ph.D., from the Harvard Medical School in Boston, and colleagues conducted a microsimulation model of competing mortality risks using data from the Childhood Cancer Survivor Study on five-year survivors of […]

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Obesity is a risk factor for cardiotoxicity in chemotherapy-treated patients with breast cancer

Anthracyclines remain a cornerstone of breast cancer therapy in combination with new-generation targeted drugs such as trastuzumab. Both types of drugs are major culprits in chemotherapy-induced heart disease. A recent study showed that being overweight or obese was a risk factor for cardiotoxicity in chemotherapy-treated patients with breast cancer, but it did not take into account related cardiac risk factors […]

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Hear this: Healthful diet tied to lower risk of hearing loss

Investigators from Brigham and Women’s Hospital have found that eating a healthy diet may reduce the risk of acquired hearing loss. Using longitudinal data collected in the Nurses’ Health Study II Conservation of Hearing Study (CHEARS), researchers examined three-year changes in hearing sensitivities and found that women whose eating patterns more closely adhered to commonly recommended healthful dietary patterns, such […]

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Screening tool administered in pediatric ER accurately gauges suicide risk

A suicide risk screening tool that Johns Hopkins Medicine implemented in its pediatric emergency department six years ago appears to provide an accurate gauge of which youth are most vulnerable and has identified more than 2,000 patients who might benefit from mental health treatment and resources, according to a study led by researchers at Johns Hopkins Bloomberg School of Public […]

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Schizophrenia risk gene linked to cognitive deficits in mice

Researchers have discovered in mice how one of the few genes definitively linked to schizophrenia, called SETD1A, likely confers risk for the illness. Mice genetically engineered to lack a functioning version of the enzyme-coding gene showed abnormalities in working memory, mimicking those commonly seen in schizophrenia patients. Restoring the gene’s function corrected the working memory deficit. Counteracting the gene’s deficiencies […]

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Researchers find risk factors for unemployment with multiple sclerosis vary by age

A recent study by Kessler Foundation researchers explored numerous factors that contribute to the high unemployment rate among individuals of different ages with multiple sclerosis (MS). This is the first investigation to consider age within the context of disease- and person-specific factors affecting employment in MS. The article, “Unemployment in multiple sclerosis across the ages: How factors of unemployment differ […]

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