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America’s national retailers are preparing to make a comeback after shuttering for several months due to the coronavirus pandemic. And while we can expect to see our favorite names including Macy’s, Nordstrom, and Gap reopen soon, everyone is gearing up to operate under a new normal, where social distancing rules, regular temperature checks, and face masks apply. When clothing giant […]
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Regulatory T cells (Tregs) prevent excessive immune reactions in healthy people. In the development of autoimmune type 1 diabetes, this protection is not sufficiently effective. Researchers at Helmholtz Zentrum München and LMU Munich have now deciphered a mechanism that impairs Treg differentiation and stability. In the study, when researchers inhibited the molecule that triggers this mechanism, an increased number of […]
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(HealthDay)—Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients, according to a study published online Aug. 6 in the Journal of Clinical Oncology. Clare J. Twist, M.D., from the Roswell Park Cancer Institute in Buffalo, New York, and colleagues enrolled 404 evaluable patients between 2007 and 2011 […]
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Researchers from TARA Biosystems, Inc. and GlaxoSmithKline (GSK) today published data demonstrating that TARA’s engineered heart-on-a-chip system replicated drug responses found in adult humans. The findings, published in the journal Toxicological Sciences, show TARA’s 3-D-cardiac tissue platform can predict how human hearts will respond to a wide range of drugs, something that has been a challenge in pre-clinical models until […]
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A novel imaging test shows promise for identifying kidney cancer patients most likely to benefit from immunotherapy. In a study published today in the Journal for ImmunoTherapy of Cancer, investigators with the UT Southwestern Medical Center Kidney Cancer Program developed a new test to illuminate kidney cancers that may respond to checkpoint inhibitors. The strategy involved transforming an immunotherapy drug, […]
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Immunotherapy, using the body’s own immune system to target and destroy cancer cells, is one of the most promising frontiers in cancer research, but many patients do not respond to the therapies for reasons not fully understood. Scientists at the Yale Systems Biology Institute have taken a step closer to understanding how the genetic makeup of cancer cells directs the […]
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Cervical cancer rates can be greatly reduced through preventive measures against the human papillomavirus (HPV) along with proactive cancer screening. Japan may be showing how ignoring that knowledge could prove hazardous, as it is the only advanced economy in which the cervical cancer rate is increasing. New research adds further nuance to this situation. Researchers centered at Osaka University examined […]
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Taking typical daily annoyances such as a long wait at the doctor’s office or a traffic jam on the freeway in stride may help preserve brain health in older adults, while emotional reactions could contribute to declines in cognition, a new study from Oregon State University has found. “These results confirm that people’s daily emotions and how they respond to […]
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Pre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major pathological responses in 100 percent of early-stage colon cancers with mismatch repair deficiencies, according to results reported at ESMO 2018 from the first exploratory phase II trial to investigate this approach. Restoring patients’ immune response against cancer cells with checkpoint inhibitors is an established treatment […]
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Data from a clinical trial has shown that how people respond to treatment for Bipolar Disorder may be influenced by their weight and the overall quality of their diet, including whether they are eating a diet high in foods thought to contribute to general inflammation. These are early results, but if replicated may mean that treatment of some mental health […]
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