Researchers identify a possible cause and treatment for inflammatory bowel disease

Inflammatory bowel disease (IBD) is a category of refractory inflammatory disease, of which ulcerative colitis (UC) and Crohn’s disease (CD) are the main types. Current studies suggest that IBD is a complex autoinflammatory disease determined by genetic and environmental factors, and is the major cause of gastrointestinal cancer. Because of its complex and refractory character, researchers have focused on determining […]

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Uncovering possible role of polyphosphate in dialysis-related amyloidosis

Long-term dialysis treatment is tough on the body in many ways, but one of the most serious complications is dialysis-related amyloidosis, a disease characterized by abnormal buildup of protein aggregates—called amyloid fibrils—in joints, tissues and organs. Although there is no cure, recent research by Osaka University researchers sheds light on how amyloid fibrils form and aggregate, thereby allowing the identification […]

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DF-PGT, now possible through massive sequencing techniques

A research team from the Universitat Autònoma de Barcelona (UAB), in collaboration with the Blood and Tissue Bank of Catalonia, has implemented a massive sequencing platform for preimplantation genetic testing (PGT) for the first time in history. The work adapts the TruSight One (TSO) platform, one of today’s most complete genetic panels, to Double Factor Preimplantation Genetic Testing (DF-PGT). The […]

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Interim guidance provided for men with possible Zika infection

(HealthDay)—Interim guidance recommends that men with possible Zika virus infection wait three months before trying to conceive or engaging in unprotected sex, according to research published in the Aug. 10 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report. Kara D. Polen, M.P.H., from the CDC in Atlanta, and colleagues updated interim guidance for […]

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Research shows it’s possible to reverse damage caused by aging cells

What’s the secret to aging well? University of Minnesota Medical School researchers have answered it- on a cellular level. Aging starts in our cells, and those aging cells can hasten cellular senescence, leading to tissue dysfunction and related health impacts. New research involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer, recently published in Nature […]

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New diagnostic blood test helps rule out need for CT scans in some patients with possible traumatic brain injuries

Research conducted at the Wayne State University School of Medicine has helped confirm the effectiveness of a blood biomarker that can indicate if patients with a head injury can avoid a costly CT scan because the blood test results indicate no traumatic brain injury (TBI). The findings, published online in The Lancet Neurology on July 24, validated the use of […]

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Enzyme identified as possible novel drug target for sickle cell disease, Thalassemia

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease (SCD). Experiments in cultured human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name. “We […]

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Research identifies possible new pathway to treat anxiety

Researchers know that anxiety is a result of repeated stress. William Colmers, a University of Alberta professor in the Department of Pharmacology, is trying to understand why stress affects people differently, and to identify possible new therapeutic approaches to anxiety disorders. The body is designed to deal with stress thanks to a “fight or flight” response that helps prepare your […]

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Possible new treatment for spinal cord injuries identified in animal studies

An experimental drug has shown promise as a potential therapy for spinal cord injuries in animal studies. The compound, 4-aminopyridine-3-methanol, works in a similar way as a drug previously developed at Purdue, 4-aminopyridine (4-AP), which has been approved by the U.S. Food and Drug Administration to treat multiple sclerosis. Dr. Riyi Shi, professor in the Department of Basic Medical Sciences, […]

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